Oxidative Stress Markers in Intestinal Mucosa of Tunisian Inflammatory Bowel Disease Patients

Overview

Journal Saudi J Gastroenterol

Specialty Gastroenterology

Date 2013 May 18

PMID 23680711

Citations 20

Authors

Dorra Bouzid

Bochra Gargouri

Riadh Ben Mansour

Ali Amouri

Nabil Tahri

Saloua Lassoued

Hatem Masmoudi

Affiliations

Soon will be listed here.

Abstract

Unlabelled: BACKGROUND / AIMS: Inflammatory bowel diseases (IBDs), Crohn's disease (CrD) and ulcerative colitis (UC), are chronic gastrointestinal inflammatory disorders. The precise etiology of IBD remains unclear, and it is thought that interactions among various factors, including, genetic factors, the host immune system and environmental factors, cause disruption of intestinal homeostasis, leading to dysregulated inflammatory responses of the gut. As inflammation is intimately related to formation of reactive intermediates, including, reactive oxygen species, oxidative stress has been proposed as a mechanism underlying the pathophysiology of IBD. The purpose of this study is to examine the lipid peroxidation, protein oxidation and anti-oxidative profile in Tunisian IBD.

Materials And Methods: Malondialdehyde (MDA), conjugated dienes (CD), protein thiol levels, as well as the catalase (CAT) activity were evaluated in intestinal biopsies of 17 patients affected by IBD (12 CrD and 5 UC) and 12 healthy control individuals.

Results: Oxidative stress was confirmed in these two types of disease biopsies as compared to controls. MDA and CD levels were significantly increased in both UC and CrD patients' biopsies as compared to controls' biopsies ( P < 0.001). CAT activity was similar in UC and CrD biopsies' and was not significantly increased in IBD patients' biopsies compared with controls' biopsies ( P > 0.05). Anon-significant decrease in thiol (SH) level was observed in both UC and CrD patients' biopsies compared with controls' biopsies ( P > 0.05).

Conclusion: Increased levels of MDA and CD in IBD patients' biopsies underline the implication of oxidative stress in the physiopathology of IBD.

Citing Articles

Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?.

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Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease.

Merino de Paz N, Carrillo-Palau M, Hernandez-Camba A, Abreu-Gonzalez P, de Vera-Gonzalez A, Gonzalez-Delgado A Antioxidants (Basel). 2024; 13(10).

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The emerging role of oxidative stress in inflammatory bowel disease.

Muro P, Zhang L, Li S, Zhao Z, Jin T, Mao F Front Endocrinol (Lausanne). 2024; 15:1390351.

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Thiols as a marker of inflammatory bowel disease activity: a systematic review.

Passos R, Costa P, da Maia Lima C, Santana G, David V, de Jesus Santos G BMC Gastroenterol. 2023; 23(1):94.

PMID: 36977983 PMC: 10052829. DOI: 10.1186/s12876-023-02711-9.

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