Cyclophilin 20-3 Relays a 12-oxo-phytodienoic Acid Signal During Stress Responsive Regulation of Cellular Redox Homeostasis

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2013 May 15

PMID 23671085

Citations 100

Authors

Sang-Wook Park

Wei Li

Andrea Viehhauser

Bin He

Soonok Kim

Anders K Nilsson

Mats X Andersson

Joshua D Kittle

Madana M R Ambavaram

Sheng Luan

Alan R Esker

Dorothea Tholl

Daniela Cimini

Mats Ellerstrom

Gitta Coaker

Thomas K Mitchell

Andy Pereira

Karl-Josef Dietz

Christopher B Lawrence

Affiliations

Soon will be listed here.

Abstract

The jasmonate family of phytohormones plays central roles in plant development and stress acclimation. However, the architecture of their signaling circuits remains largely unknown. Here we describe a jasmonate family binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-responsive cellular redox homeostasis. (+)-12-Oxo-phytodienoic acid (OPDA) binding promotes CYP20-3 to form a complex with serine acetyltransferase 1, which triggers the formation of a hetero-oligomeric cysteine synthase complex with O-acetylserine(thiol)lyase B in chloroplasts. The cysteine synthase complex formation then activates sulfur assimilation that leads to increased levels of thiol metabolites and the buildup of cellular reduction potential. The enhanced redox capacity in turn coordinates the expression of a subset of OPDA-responsive genes. Thus, we conclude that CYP20-3 is a key effector protein that links OPDA signaling to amino acid biosynthesis and cellular redox homeostasis in stress responses.

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