Assessing Genome-wide Statistical Significance for Large P Small N Problems

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 2013 May 14

PMID 23666935

Citations 20

Authors

Guoqing Diao

Anand N Vidyashankar

Affiliations

Soon will be listed here.

Abstract

Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.

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