Renal Insufficiency in Ghanaian HIV Infected Patients: Need for Dose Adjustment

Overview

Journal Afr Health Sci

Date 2013 May 10

PMID 23658575

Citations 12

Authors

W K B A Owiredu

L Quaye

N Amidu

O Addai-Mensah

Affiliations

Soon will be listed here.

Abstract

Background: Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency.

Objective: To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients.

Method: In estimating renal insufficiency in Ghanaian HIV-infected patients, GFR for 276 HAART-naïve patients and 166 patients on HAART was estimated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI estimating equations.

Results: Females outnumbered males by 3 to 1 in the HAART-naïve group and 4 to 1 in subjects on HAART. The prevalence of renal insufficiency calculated with the Cockcroft-Gault, 4v-MDRD and CKD-EPI equations was 8.7%, 9.1% and 8.7% in HAART-naïve patients; 14.5%, 12.6% and 12.6% in patients on HAART; 7.7%, 11.5% and 11.5% in HAART-naïve males; 10.8%, 8.1% and 8.1% in males on HAART; 9.1%, 8.0% and 7.5% in HAART-naïve females and 15.5%, 14.0% and 14.0% in females on HAART. The CKD-EPI equation yielded lower bias when compared to the Cockcroft-Gault and 4v-MDRD equations.

Conclusion: Renal insufficiency is not uncommon among HIV infected Ghanaian patients. A significant proportion (10 to 11%) will require ARV dose adjustment at the time of initiating therapy or sometime during on-going therapy.

Citing Articles

Chronic kidney disease and its predictors among highly active antiretroviral therapy naïve and experienced HIV-infected individuals at the selected hospitals, Southwest Ethiopia: a comparative cross-sectional study.

Belay A, Manaye G, Kebede K, Abateneh D, Debebe S BMJ Public Health. 2025; 1(1):e000235.

PMID: 40017843 PMC: 11812716. DOI: 10.1136/bmjph-2023-000235.

Renal Function Impairment and Associated Factors Among Adult HIV-Positive Patients Attending Antiretroviral Therapy Clinic in Mettu Karl Referral Hospital: Cross-Sectional Study.

Kefeni B, Hajito K, Getnet M HIV AIDS (Auckl). 2021; 13:631-640.

PMID: 34135641 PMC: 8200135. DOI: 10.2147/HIV.S301748.

Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia.

Manaye G, Abateneh D, Niguse W HIV AIDS (Auckl). 2020; 12:591-599.

PMID: 33116921 PMC: 7585507. DOI: 10.2147/HIV.S276356.

Chronic kidney disease in patients infected with human immunodeficiency virus (HIV) in an urban cohort.

Brito R, Nguyen D, Johnson J, Lai E, Castro R, Albert A PLoS One. 2019; 14(4):e0215575.

PMID: 30995263 PMC: 6469809. DOI: 10.1371/journal.pone.0215575.

Serum creatinine and estimated glomerular filtration rates in HIV positive and negative adults in Ethiopia.

Yilma D, Abdissa A, Kaestel P, Tesfaye M, Olsen M, Girma T PLoS One. 2019; 14(2):e0211630.

PMID: 30753190 PMC: 6372225. DOI: 10.1371/journal.pone.0211630.

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