Effects of Oxytocin on Behavioral and ERP Measures of Recognition Memory for Own-race and Other-race Faces in Women and Men

Overview

Journal Psychoneuroendocrinology

Specialties Endocrinology
Neurology
Psychiatry

Date 2013 May 8

PMID 23648370

Citations 14

Authors

Grit Herzmann

Christopher W Bird

Megan Freeman

Tim Curran

Affiliations

Soon will be listed here.

Abstract

Oxytocin has been shown to affect human social information processing including recognition memory for faces. Here we investigated the neural processes underlying the effect of oxytocin on memorizing own-race and other-race faces in men and women. In a placebo-controlled, double-blind, between-subject study, participants received either oxytocin or placebo before studying own-race and other-race faces. We recorded event-related potentials (ERPs) during both the study and recognition phase to investigate neural correlates of oxytocin's effect on memory encoding, memory retrieval, and perception. Oxytocin increased the accuracy of familiarity judgments in the recognition test. Neural correlates for this effect were found in ERPs related to memory encoding and retrieval but not perception. In contrast to its facilitating effects on familiarity, oxytocin impaired recollection judgments, but in men only. Oxytocin did not differentially affect own-race and other-race faces. This study shows that oxytocin influences memory, but not perceptual processes, in a face recognition task and is the first to reveal sex differences in the effect of oxytocin on face memory. Contrary to recent findings in oxytocin and moral decision making, oxytocin did not preferentially improve memory for own-race faces.

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References

Bartz J, Zaki J, Bolger N, Ochsner K . Social effects of oxytocin in humans: context and person matter. Trends Cogn Sci. 2011; 15(7):301-9. DOI: 10.1016/j.tics.2011.05.002. View

van IJzendoorn M, Bakermans-Kranenburg M . A sniff of trust: meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group. Psychoneuroendocrinology. 2011; 37(3):438-43. DOI: 10.1016/j.psyneuen.2011.07.008. View

MacDonald K, MacDonald T . The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans. Harv Rev Psychiatry. 2010; 18(1):1-21. DOI: 10.3109/10673220903523615. View

Carmichael M, Warburton V, Dixen J, Davidson J . Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav. 1994; 23(1):59-79. DOI: 10.1007/BF01541618. View

Latinus M, Taylor M . Face processing stages: impact of difficulty and the separation of effects. Brain Res. 2006; 1123(1):179-87. DOI: 10.1016/j.brainres.2006.09.031. View

Duchaine B, Nakayama K . The Cambridge Face Memory Test: results for neurologically intact individuals and an investigation of its validity using inverted face stimuli and prosopagnosic participants. Neuropsychologia. 2005; 44(4):576-85. DOI: 10.1016/j.neuropsychologia.2005.07.001. View

Vilberg K, Moosavi R, Rugg M . The relationship between electrophysiological correlates of recollection and amount of information retrieved. Brain Res. 2006; 1122(1):161-70. PMC: 1713226. DOI: 10.1016/j.brainres.2006.09.023. View

Savaskan E, Ehrhardt R, Schulz A, Walter M, Schachinger H . Post-learning intranasal oxytocin modulates human memory for facial identity. Psychoneuroendocrinology. 2008; 33(3):368-74. DOI: 10.1016/j.psyneuen.2007.12.004. View

Zink C, Meyer-Lindenberg A . Human neuroimaging of oxytocin and vasopressin in social cognition. Horm Behav. 2012; 61(3):400-9. PMC: 3312952. DOI: 10.1016/j.yhbeh.2012.01.016. View

10.

Spaniol J, Davidson P, Kim A, Han H, Moscovitch M, Grady C . Event-related fMRI studies of episodic encoding and retrieval: meta-analyses using activation likelihood estimation. Neuropsychologia. 2009; 47(8-9):1765-79. DOI: 10.1016/j.neuropsychologia.2009.02.028. View

11.

Smeltzer M, Curtis J, Aragona B, Wang Z . Dopamine, oxytocin, and vasopressin receptor binding in the medial prefrontal cortex of monogamous and promiscuous voles. Neurosci Lett. 2005; 394(2):146-51. DOI: 10.1016/j.neulet.2005.10.019. View

12.

de Vries G . Sex differences in vasopressin and oxytocin innervation of the brain. Prog Brain Res. 2008; 170:17-27. DOI: 10.1016/S0079-6123(08)00402-0. View

13.

Herzmann G, Curran T . Experts' memory: an ERP study of perceptual expertise effects on encoding and recognition. Mem Cognit. 2011; 39(3):412-32. DOI: 10.3758/s13421-010-0036-1. View

14.

Paller K, Kutas M, Mayes A . Neural correlates of encoding in an incidental learning paradigm. Electroencephalogr Clin Neurophysiol. 1987; 67(4):360-71. DOI: 10.1016/0013-4694(87)90124-6. View

15.

Rimmele U, Hediger K, Heinrichs M, Klaver P . Oxytocin makes a face in memory familiar. J Neurosci. 2009; 29(1):38-42. PMC: 6664913. DOI: 10.1523/JNEUROSCI.4260-08.2009. View

16.

Voss J, Paller K . Remembering and knowing: electrophysiological distinctions at encoding but not retrieval. Neuroimage. 2009; 46(1):280-9. DOI: 10.1016/j.neuroimage.2009.01.048. View

17.

Rugg M, Curran T . Event-related potentials and recognition memory. Trends Cogn Sci. 2007; 11(6):251-7. DOI: 10.1016/j.tics.2007.04.004. View

18.

Domes G, Lischke A, Berger C, Grossmann A, Hauenstein K, Heinrichs M . Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology. 2009; 35(1):83-93. DOI: 10.1016/j.psyneuen.2009.06.016. View

19.

Carmichael M, HUMBERT R, Dixen J, Palmisano G, Greenleaf W, Davidson J . Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab. 1987; 64(1):27-31. DOI: 10.1210/jcem-64-1-27. View

20.

Herzmann G, Young B, Bird C, Curran T . Oxytocin can impair memory for social and non-social visual objects: a within-subject investigation of oxytocin's effects on human memory. Brain Res. 2012; 1451:65-73. PMC: 3334403. DOI: 10.1016/j.brainres.2012.02.049. View