Cytokine Gene Polymorphism and Graft-versus-host Disease: a Survey in Iranian Bone Marrow Transplanted Patients

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2013 May 7

PMID 23645090

Citations 4

Authors

Mohammad Reza Noori-Daloii

Nazanin Jalilian

Pantea Izadi

Maryam Sobhani

Zeinab Rabii-Gilani

Mir Saeed Yekaninejad

Affiliations

Soon will be listed here.

Abstract

Graft versus host disease (GVHD) is a major complication of bone marrow transplantation (BMT). Numerous studies have shown the potential role of cytokine genotypes in the occurrence of GVHD. In this retrospective, case-control study we aimed to investigate the association between 13 cytokine genes and acute GVHD (aGVHD) after HLA-identical sibling BMT in 91 Iranian subjects. Negative association was found between aGVHD and donor IL-10/GCC haplotype or donor IL-4Ra-A allele in the population study. When compared within the leukemia subgroup, we observed positive association between recipient IL-1α -889/C allele and aGVHD. Also there were negative association between recipient IL-10/CAA haplotype and donor IL-4Ra/A allele and development of aGVHD. Among the different genotypes only donor IL-4Ra and donor IL-12 showed significant association. We conclude that several cytokine polymorphisms are positively and negatively associated with aGVHD in Iranian HLA matched siblings, of which IL-4Ra and IL-12 may play important roles.

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