Population Genomics of Post-vaccine Changes in Pneumococcal Epidemiology

Overview

Journal Nat Genet

Specialty Genetics

Date 2013 May 7

PMID 23644493

Citations 223

Authors

Nicholas J Croucher

Jonathan A Finkelstein

Stephen I Pelton

Patrick K Mitchell

Grace M Lee

Julian Parkhill

Stephen D Bentley

William P Hanage

Marc Lipsitch

Affiliations

Soon will be listed here.

Abstract

Whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant before the introduction of the vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction.

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