SATB1 is Overexpressed in Metastatic Prostate Cancer and Promotes Prostate Cancer Cell Growth and Invasion

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2013 May 7

PMID 23642278

Citations 36

Authors

Lijun Mao

Chunhua Yang

Junqi Wang

Wang Li

Rumin Wen

Jiacun Chen

Junnian Zheng

Affiliations

Soon will be listed here.

Abstract

Background: Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as the global chromatin organizer to regulate chromatin structure and gene expression gene expression. SATB1 has been shown to be abnormally expressed in various types of cancer. However, the expression and role of SATB1 in prostate cancer remain unclear.

Methods: 120 cases of prostatic carcinoma and 60 cases of benign prostate hyperplasia were analyzed for SATB1 expression by immunohistochemistry. LNCaP, DU-145, and PC3 prostate cancer cells were examined for SATB1 expression by Western blot analysis. Cell proliferation and invasion was evaluated by CCK8 and transwell invasion assay, respectively.

Results: SATB1 staining was stronger in prostatic carcinomas with metastasis than in those without metastasis, but was absent in benign prostate hyperplasia. Furthermore, SATB1 expression was positively correlated with bone metastasis and the Gleason score. SATB1 overexpression promoted the proliferation and invasion of LNCaP cells while SATB1 knockdown inhibited the proliferation and invasion of DU-145 cells.

Conclusions: These findings provide novel insight into oncogenic role of SATB1 in prostate cancer, suggesting that SATB1 is a promising biomarker and therapeutic target for prostate cancer.

Citing Articles

SATB1 in cancer progression and metastasis: mechanisms and therapeutic potential.

Bai J, Yang G, Yu Q, Chi Q, Zeng X, Qi W Front Oncol. 2025; 15:1535929.

PMID: 40071088 PMC: 11893431. DOI: 10.3389/fonc.2025.1535929.

Purine-Rich Element Binding Protein Alpha, a Nuclear Matrix Protein, Has a Role in Prostate Cancer Progression.

Inoue T, Bao X, Kageyama T, Sugino Y, Sekito S, Miyachi S Int J Mol Sci. 2024; 25(13).

PMID: 39000020 PMC: 11241608. DOI: 10.3390/ijms25136911.

Adaptive and non-adaptive gene expression responses in prostate cancer during androgen deprivation.

Natkin R, Pennanen P, Syvala H, Blauer M, Kesseli J, Tammela T PLoS One. 2023; 18(2):e0281645.

PMID: 36809527 PMC: 9942993. DOI: 10.1371/journal.pone.0281645.

3D Genome Organization as an Epigenetic Determinant of Transcription Regulation in T Cells.

Papadogkonas G, Papamatheakis D, Spilianakis C Front Immunol. 2022; 13:921375.

PMID: 35812421 PMC: 9257000. DOI: 10.3389/fimmu.2022.921375.

SATB1, genomic instability and Gleason grading constitute a novel risk score for prostate cancer.

Dumke C, Gemoll T, Oberlander M, Freitag-Wolf S, Thorns C, Glaessgen A Sci Rep. 2021; 11(1):24446.

PMID: 34961766 PMC: 8712510. DOI: 10.1038/s41598-021-03702-0.

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