Chlamydial Intracellular Survival Strategies

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2013 May 3

PMID 23637308

Citations 116

Authors

Robert J Bastidas

Cherilyn A Elwell

Joanne N Engel

Raphael H Valdivia

Affiliations

Soon will be listed here.

Abstract

Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the causative agent of blinding trachoma. Although Chlamydia is protected from humoral immune responses by residing within remodeled intracellular vacuoles, it still must contend with multilayered intracellular innate immune defenses deployed by its host while scavenging for nutrients. Here we provide an overview of Chlamydia biology and highlight recent findings detailing how this vacuole-bound pathogen manipulates host-cellular functions to invade host cells and maintain a replicative niche.

Citing Articles

Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease.

Spencer P, Wang J, Smith E, Spiga L, Simmons A, Kim T bioRxiv. 2025; .

PMID: 39803424 PMC: 11722351. DOI: 10.1101/2025.01.04.630951.

Interplay of Transcriptomic Regulation, Microbiota, and Signaling Pathways in Lung and Gut Inflammation-Induced Tumorigenesis.

Otalora-Otalora B, Payan-Gomez C, Lopez-Rivera J, Pedroza-Aconcha N, Arboleda-Mojica S, Aristizabal-Guzman C Cells. 2025; 14(1.

PMID: 39791702 PMC: 11720097. DOI: 10.3390/cells14010001.

The SWIB domain-containing DNA topoisomerase I of mediates DNA relaxation.

Shen L, Diggs C, Ferdous S, Santos A, Wolf N, Terrebonne A bioRxiv. 2024; .

PMID: 39677648 PMC: 11642884. DOI: 10.1101/2024.12.03.626651.

: A zoonotic pathogen causing avian chlamydiosis and psittacosis.

Wang J, Wang B, Xiao J, Chen Y, Wang C Virulence. 2024; 15(1):2428411.

PMID: 39541409 PMC: 11622591. DOI: 10.1080/21505594.2024.2428411.

Inc Ct226 is vital for FLI1 and LRRF1 recruitment to the chlamydial inclusion.

Sturd N, Knight L, Wood M, Durham L, Ouellette S, Rucks E mSphere. 2024; 9(11):e0047324.

PMID: 39404459 PMC: 11580450. DOI: 10.1128/msphere.00473-24.

References

Mehlitz A, Banhart S, Hess S, Selbach M, Meyer T . Complex kinase requirements for Chlamydia trachomatis Tarp phosphorylation. FEMS Microbiol Lett. 2008; 289(2):233-40. DOI: 10.1111/j.1574-6968.2008.01390.x. View

Delevoye C, Nilges M, Dautry-Varsat A, Subtil A . Conservation of the biochemical properties of IncA from Chlamydia trachomatis and Chlamydia caviae: oligomerization of IncA mediates interaction between facing membranes. J Biol Chem. 2004; 279(45):46896-906. DOI: 10.1074/jbc.M407227200. View

Hower S, Wolf K, Fields K . Evidence that CT694 is a novel Chlamydia trachomatis T3S substrate capable of functioning during invasion or early cycle development. Mol Microbiol. 2009; 72(6):1423-37. PMC: 2997736. DOI: 10.1111/j.1365-2958.2009.06732.x. View

Su H, McClarty G, Dong F, Hatch G, Pan Z, Zhong G . Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J Biol Chem. 2003; 279(10):9409-16. DOI: 10.1074/jbc.M312008200. View

Bebear C, De Barbeyrac B . Genital Chlamydia trachomatis infections. Clin Microbiol Infect. 2009; 15(1):4-10. DOI: 10.1111/j.1469-0691.2008.02647.x. View

Kalman S, Mitchell W, Marathe R, Lammel C, Fan J, HYMAN R . Comparative genomes of Chlamydia pneumoniae and C. trachomatis. Nat Genet. 1999; 21(4):385-9. DOI: 10.1038/7716. View

Dong F, Pirbhai M, Xiao Y, Zhong Y, Wu Y, Zhong G . Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells. Infect Immun. 2005; 73(3):1861-4. PMC: 1064967. DOI: 10.1128/IAI.73.3.1861-1864.2005. View

Wang J, Zhang Y, Lu C, Lei L, Yu P, Zhong G . A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans. J Immunol. 2010; 185(3):1670-80. DOI: 10.4049/jimmunol.1001240. View

Darville T, ONeill J, Andrews Jr C, Nagarajan U, Stahl L, Ojcius D . Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol. 2003; 171(11):6187-97. DOI: 10.4049/jimmunol.171.11.6187. View

10.

Rejman Lipinski A, Heymann J, Meissner C, Karlas A, Brinkmann V, Meyer T . Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation. PLoS Pathog. 2009; 5(10):e1000615. PMC: 2752117. DOI: 10.1371/journal.ppat.1000615. View

11.

Suchland R, Sandoz K, Jeffrey B, Stamm W, Rockey D . Horizontal transfer of tetracycline resistance among Chlamydia spp. in vitro. Antimicrob Agents Chemother. 2009; 53(11):4604-11. PMC: 2772348. DOI: 10.1128/AAC.00477-09. View

12.

DeMars R, Weinfurter J . Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance. J Bacteriol. 2007; 190(5):1605-14. PMC: 2258673. DOI: 10.1128/JB.01592-07. View

13.

Rank R, Bowlin A, Kelly K . Characterization of lymphocyte response in the female genital tract during ascending Chlamydial genital infection in the guinea pig model. Infect Immun. 2000; 68(9):5293-8. PMC: 101791. DOI: 10.1128/IAI.68.9.5293-5298.2000. View

14.

Le Negrate G, Krieg A, Faustin B, Loeffler M, Godzik A, Krajewski S . ChlaDub1 of Chlamydia trachomatis suppresses NF-kappaB activation and inhibits IkappaBalpha ubiquitination and degradation. Cell Microbiol. 2008; 10(9):1879-92. DOI: 10.1111/j.1462-5822.2008.01178.x. View

15.

Gabel B, Elwell C, van Ijzendoorn S, Engel J . Lipid raft-mediated entry is not required for Chlamydia trachomatis infection of cultured epithelial cells. Infect Immun. 2004; 72(12):7367-73. PMC: 529103. DOI: 10.1128/IAI.72.12.7367-7373.2004. View

16.

Germain R . MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell. 1994; 76(2):287-99. DOI: 10.1016/0092-8674(94)90336-0. View

17.

Buchholz K, Stephens R . The cytosolic pattern recognition receptor NOD1 induces inflammatory interleukin-8 during Chlamydia trachomatis infection. Infect Immun. 2008; 76(7):3150-5. PMC: 2446689. DOI: 10.1128/IAI.00104-08. View

18.

Prantner D, Darville T, Nagarajan U . Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection. J Immunol. 2010; 184(5):2551-60. PMC: 2863030. DOI: 10.4049/jimmunol.0903704. View

19.

Netea M, Kullberg B, Jacobs L, Verver-Jansen T, van der Ven-Jongekrijg J, Galama J . Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release. J Immunol. 2004; 173(2):1477-82. DOI: 10.4049/jimmunol.173.2.1477. View

20.

Lad S, Yang G, Scott D, Wang G, Nair P, Mathison J . Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response. J Bacteriol. 2007; 189(18):6619-25. PMC: 2045167. DOI: 10.1128/JB.00429-07. View