Cembranoids from the Soft Coral Sinularia Rigida with Antifouling Activities
Overview
Nutritional Sciences
Affiliations
Chemical examination of the soft coral Sinularia rigida resulted in the isolation of 12 new cembranoids, namely, sinulariols T-Z5 (1-12), together with a known analogue, 13. Their structures were determined on the basis of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analyses in association with MS and IR data. Compounds 7 and 13 showed potent antifouling activity for the inhibition against the barnacle Balanus amphitrite and moderate inhibition against Bugula neritina . The primary structure-activity relationship is discussed.
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