Polymorphisms in DNA Repair Pathway Genes, Body Mass Index, and Risk of Non-Hodgkin Lymphoma

Overview

Journal Am J Hematol

Specialty Hematology

Date 2013 Apr 27

PMID 23619945

Citations 7

Authors

Yingtai Chen

Tongzhang Zheng

Qing Lan

Christopher Kim

Qin Qin

Francine Foss

Xuezhong Chen

Theodore Holford

Brian Leaderer

Peter Boyle

Chengfeng Wang

Min Dai

Zhenjiang Liu

Shuangge Ma

Stephen J Chanock

Nathaniel Rothman

Yawei Zhang

Affiliations

Soon will be listed here.

Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.

Citing Articles

The Role of DNA Repair (, , , and Gene Polymorphisms in the Development of Myeloproliferative Neoplasms.

Crisan A, Tripon F, Boglis A, Crauciuc G, Trifa A, Lazar E Medicina (Kaunas). 2024; 60(3).

PMID: 38541232 PMC: 10972134. DOI: 10.3390/medicina60030506.

Screening of BRCA1 variants c.190T>C, 1307delT, g.5331G>A and c.2612C>T in breast cancer patients from North India.

Kour A, Sambyal V, Guleria K, Singh N, Uppal M, Manjari M Genet Mol Biol. 2020; 43(2):e20190014.

PMID: 32453341 PMC: 7250277. DOI: 10.1590/1678-4685-GMB-2019-0014.

Novel Associations between BRCA1 Variants C.181 T>G (Rs28897672) and Ovarian Crisk in Saudi Females.

Alyahri N, Abdi S, Khan W, Elrobh M, Addar M, Babay Z J Med Biochem. 2019; 38(1):13-21.

PMID: 30820179 PMC: 6298454. DOI: 10.2478/jomb-2018-0037.

Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.

Tong Y, Xiang Y, Li B, Bao S, Zhou Y, Yuan W Med Sci Monit. 2018; 24:7015-7022.

PMID: 30279407 PMC: 6179170. DOI: 10.12659/MSM.908813.

Association between BRCA1 P871L polymorphism and cancer risk: evidence from a meta-analysis.

Miao L, Yu Y, Ji Y, Zhang B, Yuan Z, Du Y Oncotarget. 2017; 8(18):30587-30594.

PMID: 28427168 PMC: 5444767. DOI: 10.18632/oncotarget.15739.

References

Samanic C, Chow W, Gridley G, Jarvholm B, Fraumeni Jr J . Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control. 2006; 17(7):901-9. DOI: 10.1007/s10552-006-0023-9. View

Povey A, Margison G, Santibanez-Koref M . Lung cancer risk and variation in MGMT activity and sequence. DNA Repair (Amst). 2007; 6(8):1134-44. DOI: 10.1016/j.dnarep.2007.03.022. View

Bahl S, Cotterchio M, Kreiger N, Klar N . Antidepressant medication use and non-Hodgkin's lymphoma risk: no association. Am J Epidemiol. 2004; 160(6):566-75. DOI: 10.1093/aje/kwh234. View

Cerhan J, Bernstein L, Severson R, Davis S, Colt J, Blair A . Anthropometrics, physical activity, related medical conditions, and the risk of non-hodgkin lymphoma. Cancer Causes Control. 2005; 16(10):1203-14. DOI: 10.1007/s10552-005-0358-7. View

Radak Z, Kaneko T, Tahara S, Nakamoto H, Ohno H, Sasvari M . The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes. Free Radic Biol Med. 1999; 27(1-2):69-74. DOI: 10.1016/s0891-5849(99)00038-6. View

Cheng W, Sakamoto S, Fox J, Komatsu K, Carney J, Bohr V . Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1. FEBS Lett. 2005; 579(6):1350-6. DOI: 10.1016/j.febslet.2005.01.028. View

Lunn R, Langlois R, Hsieh L, Thompson C, Bell D . XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res. 1999; 59(11):2557-61. View

Wolk A, Gridley G, Svensson M, Nyren O, McLaughlin J, Fraumeni J . A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control. 2001; 12(1):13-21. DOI: 10.1023/a:1008995217664. View

Popanda O, Schattenberg T, Phong C, Butkiewicz D, Risch A, Edler L . Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. Carcinogenesis. 2004; 25(12):2433-41. DOI: 10.1093/carcin/bgh264. View

10.

Pegg A, Byers T . Repair of DNA containing O6-alkylguanine. FASEB J. 1992; 6(6):2302-10. DOI: 10.1096/fasebj.6.6.1544541. View

11.

Rapp K, Schroeder J, Klenk J, Stoehr S, Ulmer H, Concin H . Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria. Br J Cancer. 2005; 93(9):1062-7. PMC: 2361672. DOI: 10.1038/sj.bjc.6602819. View

12.

Sato Y, Nanri H, Ohta M, Kasai H, Ikeda M . Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjects. Biochem Biophys Res Commun. 2003; 305(2):333-8. DOI: 10.1016/s0006-291x(03)00774-5. View

13.

Willett E, Skibola C, Adamson P, Skibola D, Morgan G, Smith M . Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms. Br J Cancer. 2005; 93(7):811-6. PMC: 2361643. DOI: 10.1038/sj.bjc.6602762. View

14.

Pan S, Johnson K, Ugnat A, Wen S, Mao Y . Association of obesity and cancer risk in Canada. Am J Epidemiol. 2004; 159(3):259-68. DOI: 10.1093/aje/kwh041. View

15.

Ghosh S, Lu Y, Katz A, Hu Y, Li R . Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells. Am J Physiol Endocrinol Metab. 2006; 292(1):E246-52. DOI: 10.1152/ajpendo.00242.2006. View

16.

Moller H, Mellemgaard A, Lindvig K, Olsen J . Obesity and cancer risk: a Danish record-linkage study. Eur J Cancer. 1994; 30A(3):344-50. DOI: 10.1016/0959-8049(94)90254-2. View

17.

Palitti F . Mechanisms of formation of chromosomal aberrations: insights from studies with DNA repair-deficient cells. Cytogenet Genome Res. 2004; 104(1-4):95-9. DOI: 10.1159/000077471. View

18.

Worrillow L, Roman E, Adamson P, Kane E, Allan J, Lightfoot T . Polymorphisms in the nucleotide excision repair gene ERCC2/XPD and risk of non-Hodgkin lymphoma. Cancer Epidemiol. 2009; 33(3-4):257-60. DOI: 10.1016/j.canep.2009.08.002. View

19.

Shen S, Weaver Z, Xu X, Li C, Weinstein M, Chen L . A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1999; 17(24):3115-24. DOI: 10.1038/sj.onc.1202243. View

20.

Sakamoto S, Nishikawa K, Heo S, Goto M, Furuichi Y, Shimamoto A . Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51. Genes Cells. 2001; 6(5):421-30. DOI: 10.1046/j.1365-2443.2001.00433.x. View