Chronological Changes in MicroRNA Expression in the Developing Human Brain

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Apr 25

PMID 23613727

Citations 30

Authors

Michael P Moreau

Shannon E Bruse

Rebecka Jornsten

Yushi Liu

Linda M Brzustowicz

Affiliations

Soon will be listed here.

Abstract

Objective: MicroRNAs (miRNAs) are endogenously expressed noncoding RNA molecules that are believed to regulate multiple neurobiological processes. Expression studies have revealed distinct temporal expression patterns in the developing rodent and porcine brain, but comprehensive profiling in the developing human brain has not been previously reported.

Methods: We performed microarray and TaqMan-based expression analysis of all annotated mature miRNAs (miRBase 10.0) as well as 373 novel, predicted miRNAs. Expression levels were measured in 48 post-mortem brain tissue samples, representing gestational ages 14-24 weeks, as well as early postnatal and adult time points.

Results: Expression levels of 312 miRNAs changed significantly between at least two of the broad age categories, defined as fetal, young, and adult.

Conclusions: We have constructed a miRNA expression atlas of the developing human brain, and we propose a classification scheme to guide future studies of neurobiological function.

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