RNA Structures Regulating Ribosomal Protein Biosynthesis in Bacilli

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2013 Apr 25

PMID 23611891

Citations 22

Authors

Kaila Deiorio-Haggar

Jon Anthony

Michelle M Meyer

Affiliations

Soon will be listed here.

Abstract

In Bacilli, there are three experimentally validated ribosomal-protein autogenous regulatory RNAs that are not shared with E. coli. Each of these RNAs forms a unique secondary structure that interacts with a ribosomal protein encoded by a downstream gene, namely S4, S15, and L20. Only one of these RNAs that interacts with L20 is currently found in the RNA Families Database. We created, or modified, existing structural alignments for these three RNAs and used them to perform homology searches. We have determined that each structure exhibits a narrow phylogenetic distribution, mostly relegated to the Firmicute class Bacilli. This work, in conjunction with other similar work, demonstrates that there are most likely many non-homologous RNA regulatory elements regulating ribosomal protein biosynthesis that still await discovery and characterization in other bacterial species.

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