Virulence Modulation of Streptococcus Mutans Biofilms by Metal Ions Released from Orthodontic Appliances

Overview

Journal Angle Orthod

Specialty Dentistry

Date 2013 Apr 17

PMID 23586445

Citations 4

Authors

Alinne Ulbrich Mores Rymovicz

Maiara Medeiros Ronsani

Ana Maria Trindade Gregio

Odilon Guariza Guariza-Filho

Orlando Tanaka

Edvaldo Antonio Ribeiro Rosa

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the impact of metal ions commonly shed from orthodontic appliances on the virulence of Streptococcus mutans ATCC®25175™ biofilms.

Materials And Methods: Biofilms were grown in the presence of Ni(2+), Fe(3+), Cr(3+), Co(2+), and a metal ion pool at concentrations similar to those released in saliva of orthodontic patients for 72 hours. Once mature, biofilms were treated for up to 12 hours with 5% glucose.

Results: Ions interfered with the growth of S mutans by reducing its biomass (Ni(2+), Fe(3+), Cr(3+)), raising its rates of sugar metabolism (Ni(2+), Fe(3+), Cr(3+)), and raising its secretion of lactate (Ni(2+), Fe(3+), Cr(3+), pool).

Conclusion: The laboratory data presented here point to the possibility of virulence increase of S mutans by metal ions commonly released during orthodontic therapy.

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