Aiding and Abetting Cancer: MRNA Export and the Nuclear Pore

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2013 Apr 16

PMID 23582887

Citations 37

Authors

Biljana Culjkovic-Kraljacic

Katherine L B Borden

Affiliations

Soon will be listed here.

Abstract

mRNA export is a critical step in gene expression. Export of transcripts can be modulated in response to cellular signaling or stress. Consistently, mRNA export is dysregulated in primary human specimens derived from many different forms of cancer. Aberrant expression of export factors can alter the export of specific transcripts encoding proteins involved in proliferation, survival, and oncogenesis. These specific factors, which are not used for bulk mRNA export, are obvious therapeutic targets. Indeed, given the emerging role of mRNA export in cancer, it is not surprising that efforts to target different aspects of this pathway have reached the clinical trial stage. Thus, like transcription and translation, mRNA export may also play a critical role in cancer genesis and maintenance.

Citing Articles

Nuclear mRNA export.

Chen S, Jiang Q, Fan J, Cheng H Acta Biochim Biophys Sin (Shanghai). 2024; 57(1):84-100.

PMID: 39243141 PMC: 11802349. DOI: 10.3724/abbs.2024145.

SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis.

He X, Zhang Y, Mao Z, Liu G, Huang L, Liu X Acta Biochim Biophys Sin (Shanghai). 2024; .

PMID: 39108207 PMC: 11659784. DOI: 10.3724/abbs.2024134.

eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production.

Mars J, Culjkovic-Kraljacic B, Borden K Nucleus. 2024; 15(1):2360196.

PMID: 38880976 PMC: 11185188. DOI: 10.1080/19491034.2024.2360196.

Virus Infection and mRNA Nuclear Export.

Guo J, Zhu Y, Ma X, Shang G, Liu B, Zhang K Int J Mol Sci. 2023; 24(16).

PMID: 37628773 PMC: 10454920. DOI: 10.3390/ijms241612593.

Toxic Species Affect ArfGAP-1 Function.

Rossi S, Di Salvio M, Bali M, De Simone A, Apolloni S, DAmbrosi N Cells. 2023; 12(15).

PMID: 37566088 PMC: 10416972. DOI: 10.3390/cells12152007.

References

Siddiqui N, Borden K . mRNA export and cancer. Wiley Interdiscip Rev RNA. 2011; 3(1):13-25. DOI: 10.1002/wrna.101. View

Yang J, Bogerd H, Wang P, Page D, Cullen B . Two closely related human nuclear export factors utilize entirely distinct export pathways. Mol Cell. 2001; 8(2):397-406. DOI: 10.1016/s1097-2765(01)00303-3. View

Crampton N, Kodiha M, Shrivastava S, Umar R, Stochaj U . Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1. Mol Biol Cell. 2009; 20(24):5106-16. PMC: 2793288. DOI: 10.1091/mbc.e09-05-0397. View

Walther T, Pickersgill H, Cordes V, Goldberg M, Allen T, Mattaj I . The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. J Cell Biol. 2002; 158(1):63-77. PMC: 2173022. DOI: 10.1083/jcb.200202088. View

Chin K, DeVries S, Fridlyand J, Spellman P, Roydasgupta R, Kuo W . Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. 2006; 10(6):529-41. DOI: 10.1016/j.ccr.2006.10.009. View

Faria P, Chakraborty P, Levay A, Barber G, Ezelle H, Enninga J . VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway. Mol Cell. 2005; 17(1):93-102. DOI: 10.1016/j.molcel.2004.11.023. View

Dawlaty M, Malureanu L, Jeganathan K, Kao E, Sustmann C, Tahk S . Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell. 2008; 133(1):103-15. PMC: 2693193. DOI: 10.1016/j.cell.2008.01.045. View

Saito K, Fujiwara T, Katahira J, Inoue K, Sakamoto H . TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD. Biochem Biophys Res Commun. 2004; 321(2):291-7. DOI: 10.1016/j.bbrc.2004.06.140. View

Wente S, Rout M . The nuclear pore complex and nuclear transport. Cold Spring Harb Perspect Biol. 2010; 2(10):a000562. PMC: 2944363. DOI: 10.1101/cshperspect.a000562. View

10.

Kodiha M, Tran D, Morogan A, Qian C, Stochaj U . Dissecting the signaling events that impact classical nuclear import and target nuclear transport factors. PLoS One. 2009; 4(12):e8420. PMC: 2793512. DOI: 10.1371/journal.pone.0008420. View

11.

Culjkovic-Kraljacic B, Baguet A, Volpon L, Amri A, Borden K . The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation. Cell Rep. 2012; 2(2):207-15. PMC: 3463940. DOI: 10.1016/j.celrep.2012.07.007. View

12.

Kohler A, Hurt E . Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 2007; 8(10):761-73. DOI: 10.1038/nrm2255. View

13.

Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y . ALY as a potential contributor to metastasis in human oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2012; 139(4):585-94. DOI: 10.1007/s00432-012-1361-5. View

14.

Rizzieri D, Feldman E, Dipersio J, Gabrail N, Stock W, Strair R . A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res. 2008; 14(9):2756-62. DOI: 10.1158/1078-0432.CCR-07-1372. View

15.

Gould V, Martinez N, Orucevic A, Schneider J, Alonso A . A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development. Am J Pathol. 2000; 157(5):1605-13. PMC: 1885726. DOI: 10.1016/S0002-9440(10)64798-0. View

16.

Montine K, Sonenberg N . Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature. 1990; 345(6275):544-7. DOI: 10.1038/345544a0. View

17.

Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden K . eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol. 2006; 175(3):415-26. PMC: 2064519. DOI: 10.1083/jcb.200607020. View

18.

Luna R, Rondon A, Aguilera A . New clues to understand the role of THO and other functionally related factors in mRNP biogenesis. Biochim Biophys Acta. 2011; 1819(6):514-20. DOI: 10.1016/j.bbagrm.2011.11.012. View

19.

Fujimura S, Xing Y, Takeya M, Yamashita Y, Ohshima K, Kuwahara K . Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis. Cancer Res. 2005; 65(13):5925-34. DOI: 10.1158/0008-5472.CAN-04-3259. View

20.

Ohno M, Segref A, Bachi A, Wilm M, Mattaj I . PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell. 2000; 101(2):187-98. DOI: 10.1016/S0092-8674(00)80829-6. View