Late Presentation of Giant Intrathoracic Neurofibroma with Significant Mediastinal Shift: a Case Report and Review of the Literature

Overview

Journal Case Rep Pulmonol

Publisher Wiley

Specialty Pulmonary Medicine

Date 2013 Apr 11

PMID 23573448

Citations 3

Authors

Emeka B Kesieme

Andrew E Dongo

Christopher Affusim

Georgi Prisadov

Kelechi Okonta

Clement Imoloamen

Affiliations

Soon will be listed here.

Abstract

Intrathoracic tumours in patients with Von Recklinghausen's disease have been widely reported, but there are very few cases of reported intrathoracic giant benign neurofibroma with marked mediastinal shift and superior vena cava syndrome. Patients that present with this pathology should be adequately investigated. Surgical resection has been considered curative.

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References

Korolev A, Golubev O . [A giant neurofibroma of the diaphragm]. Arkh Patol. 2002; 64(2):49-50. View

Ledbetter D, RICH D, OConnell P, Leppert M, Carey J . Precise localization of NF1 to 17q11.2 by balanced translocation. Am J Hum Genet. 1989; 44(1):20-4. PMC: 1715462. View

Patel V, Louis J, Oduntan O, Landolfo K . Intrathoracic peripheral nerve sheath tumors in patients with neurofibromatosis type 1 (von Recklinghausen disease). J Thorac Cardiovasc Surg. 2006; 131(3):736-7. DOI: 10.1016/j.jtcvs.2005.11.024. View

MEREDITH H, Valicenti J . Solitary neurofibroma of the trachea. Br J Radiol. 1978; 51(603):218-9. DOI: 10.1259/0007-1285-51-603-218. View

Rees G . Neurofibroma of the recurrent laryngeal nerve. Chest. 1971; 60(4):414-8. DOI: 10.1378/chest.60.4.414. View

El Oakley R, Grotte G . Progressive tracheal and superior vena caval compression caused by benign neurofibromatosis. Thorax. 1994; 49(4):380-1. PMC: 475377. DOI: 10.1136/thx.49.4.380. View

Ferner R, Gutmann D . International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. Cancer Res. 2002; 62(5):1573-7. View

de Andrade G, Braga O, Hisatugo M, de Paiva Neto M, Succi E, Braga F . Giant intrathoracic meningoceles associated with cutaneous neurofibromatosis type I: case report. Arq Neuropsiquiatr. 2003; 61(3A):677-81. DOI: 10.1590/s0004-282x2003000400029. View

Feldkamp M, Gutmann D, Guha A . Neurofibromatosis type 1: piecing the puzzle together. Can J Neurol Sci. 1998; 25(3):181-91. DOI: 10.1017/s0317167100033990. View

10.

Maeda M, Matsuzaki Y, Edagawa M, Shimizu T, Onitsuka T . A rapidly growing benign intrathoracic neurofibroma after lung lobectomy. Jpn J Thorac Cardiovasc Surg. 2000; 48(6):385-7. DOI: 10.1007/BF03218162. View

11.

Chow L, Shum B, Chow W . Intrathoracic vagus nerve neurofibroma and sudden death in a patient with neurofibromatosis. Thorax. 1993; 48(3):298-9. PMC: 464381. DOI: 10.1136/thx.48.3.298. View

12.

ACKERMAN L, Taylor F . Neurogenous tumors within the thorax; a clinicopathological evaluation of forty-eight cases. Cancer. 1951; 4(4):669-91. DOI: 10.1002/1097-0142(195107)4:4<669::aid-cncr2820040405>3.0.co;2-b. View

13.

Lee K, Im J, Kim I, Kim P, Han M, Kim C . Tumours involving the intrathoracic vagus and phrenic nerves demonstrated by computed tomography: anatomical features. Clin Radiol. 1991; 44(5):302-5. DOI: 10.1016/s0009-9260(05)81263-2. View

14.

Saitoh K, Nasu M, Kamiyama R, Hatakeyama S, Maruyama M, Tsuruta K . Solitary neurofibroma of the esophagus. Acta Pathol Jpn. 1985; 35(2):527-31. DOI: 10.1111/j.1440-1827.1985.tb00595.x. View