Cytokine Dysregulation Associated with Malarial Anemia in Plasmodium Yoelii Infected Mice

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2013 Apr 11

PMID 23573367

Citations 11

Authors

Lili Xu

Xiaoying Zheng

Klavs Berzins

Asok Chaudhuri

Affiliations

Soon will be listed here.

Abstract

The mechanisms of malaria anemia remain incompletely understood although much effort has been put on studies in both human and murine systems. Hematopoiesis is regulated by the proliferation, differentiation and maturation of erythropoietic progenitor cells into erythrocytes and is tightly controlled by a complex communication network of cytokines as signal mediators. The present study used the murine P. yoelii 17XNL malaria model to investigate the profile of cytokines and leukocytes throughout the entire infection. Moreover, malaria induced anemia was studied in comparison with anemia induced by hemorrhage and hemolysis. During the P. yoelii infection, the levels of erythropoietic-related cytokines, such as G-CSF, GMCSF, IL-7, and IL-17, were pronouncedly reduced, while those of regulatory cytokines, such as IL-10 and TNF-α, were constantly increased. This cytokine profile corresponded well with the cellular composition during the infection, such as drastically decreased levels of CD4(+) and CD8(+) T cells. The cytokine profile during malarial anemia showed the same characteristics as anemia induced by hemorrhage or hemolysis. This study demonstrates that a markedly dysregulated cytokine network occurred in this murine malaria model, which may open a new window of insight into the mechanisms of malaria related anemia.

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References

Bot F, Dorssers L, Wagemaker G, Lowenberg B . Stimulating spectrum of human recombinant multi-CSF (IL-3) on human marrow precursors: importance of accessory cells. Blood. 1988; 71(6):1609-14. View

Evans K, Hansen D, van Rooijen N, Buckingham L, Schofield L . Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes. Blood. 2005; 107(3):1192-9. PMC: 1895912. DOI: 10.1182/blood-2005-08-3460. View

Wahlgren M, Berzins K, Perlmann P, Persson M . Characterization of the humoral immune response in Plasmodium falciparum malaria. II. IgG subclass levels of anti-P. falciparum antibodies in different sera. Clin Exp Immunol. 1983; 54(1):135-42. PMC: 1536178. View

Bostrom S, Giusti P, Arama C, Persson J, Dara V, Traore B . Changes in the levels of cytokines, chemokines and malaria-specific antibodies in response to Plasmodium falciparum infection in children living in sympatry in Mali. Malar J. 2012; 11:109. PMC: 3366880. DOI: 10.1186/1475-2875-11-109. View

Aiello F, Keller J, Klarmann K, Dranoff G, Mazzucchelli R, Durum S . IL-7 induces myelopoiesis and erythropoiesis. J Immunol. 2007; 178(3):1553-63. DOI: 10.4049/jimmunol.178.3.1553. View

Miller K, SCHOOLEY J, Smith K, Kullgren B, Mahlmann L, Silverman P . Inhibition of erythropoiesis by a soluble factor in murine malaria. Exp Hematol. 1989; 17(4):379-85. View

Herbas M, Ueta Y, Ishibashi K, Suzuki H . Expression of erythropoietic cytokines in α-tocopherol transfer protein knockout mice with murine malaria infection. Parasitol Res. 2011; 109(5):1243-50. DOI: 10.1007/s00436-011-2367-7. View

Foti M, Granucci F, Aggujaro D, Liboi E, Luini W, Minardi S . Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site. Int Immunol. 1999; 11(6):979-86. DOI: 10.1093/intimm/11.6.979. View

Abdalla S . Hematopoiesis in human malaria. Blood Cells. 1990; 16(2-3):401-16; discussion 417-9. View

10.

Blackwell S, Krieg A . CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha. J Immunol. 2003; 170(8):4061-8. DOI: 10.4049/jimmunol.170.8.4061. View

11.

Troye-Blomberg M, Berzins K, Perlmann P . T-cell control of immunity to the asexual blood stages of the malaria parasite. Crit Rev Immunol. 1994; 14(2):131-55. DOI: 10.1615/critrevimmunol.v14.i2.20. View

12.

Abdalla S, Wickramasinghe S . A study of erythroid progenitor cells in the bone marrow of Gambian children with falciparum malaria. Clin Lab Haematol. 1988; 10(1):33-40. DOI: 10.1111/j.1365-2257.1988.tb01151.x. View

13.

Sanchez-Torres L, Rodriguez-Ropon A, Aguilar-Medina M, Favila-Castillo L . Mouse splenic CD4+ and CD8+ T cells undergo extensive apoptosis during a Plasmodium chabaudi chabaudi AS infection. Parasite Immunol. 2001; 23(12):617-26. DOI: 10.1046/j.1365-3024.2001.00422.x. View

14.

Igbeneghu C, Odaibo A, Olaleye D . Impact of asymptomatic malaria on some hematological parameters in the Iwo community in Southwestern Nigeria. Med Princ Pract. 2011; 20(5):459-63. DOI: 10.1159/000327673. View

15.

Spivak J, Toretti D, DICKERMAN H . Effect of phenylhydrazine-induced hemolytic anemia on nuclear RNA polymerase activity of the mouse spleen. Blood. 1973; 42(2):257-66. View

16.

Taylor W, Widjaja H, Basri H, Ohrt C, Taufik T, Tjitra E . Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria. Malar J. 2008; 7:259. PMC: 2642516. DOI: 10.1186/1475-2875-7-259. View

17.

Xu L, Chaudhuri A . Plasmodium yoelii: a differential fluorescent technique using Acridine Orange to identify infected erythrocytes and reticulocytes in Duffy knockout mouse. Exp Parasitol. 2005; 110(1):80-7. DOI: 10.1016/j.exppara.2005.02.004. View

18.

Burgmann H, Looareesuwan S, Kapiotis S, Viravan C, Vanijanonta S, Hollenstein U . Serum levels of erythropoietin in acute Plasmodium falciparum malaria. Am J Trop Med Hyg. 1996; 54(3):280-3. DOI: 10.4269/ajtmh.1996.54.280. View

19.

Jovcic G, Bugarski D, Petakov M, Stankovic J, Stojanovic N, Milenkovic P . Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. Growth Factors. 2001; 19(1):61-71. DOI: 10.3109/08977190109001076. View

20.

Chang K, Tam M, Stevenson M . Inappropriately low reticulocytosis in severe malarial anemia correlates with suppression in the development of late erythroid precursors. Blood. 2004; 103(10):3727-35. DOI: 10.1182/blood-2003-08-2887. View