Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2019 Mar 22

PMID 30894794

Citations 6

Authors

Otchere Addai-Mensah

Daniel Gyamfi

Francis Agyei Amponsah

Max Efui Annani-Akollor

Kwabena Owusu Danquah

Lillian Boateng

Eddie-Williams Owiredu

Edward Y Afriyie

Richard Vikpebah Duneeh

Renate Asare

David Ofosu Ntiamoah

Richard Boateng

Affiliations

Soon will be listed here.

Abstract

Introduction: The pathophysiology of malaria-related anaemia is not fully understood although increased destruction of parasitized and nonparasitized erythrocytes, as well as inadequate erythropoiesis, has been proposed. Circulating antierythropoietin (anti-EPO) antibodies have also been implicated in malaria and malaria-related anaemia in mice. However, studies on this association have not been investigated in humans. This study therefore determined the prevalence of anti-EPO antibody production and assessed its association with malaria and malaria-related anaemia in humans.

Methods: A total of 86 children aged 1-10 years (57 children with malaria serving as the case group and 29 healthy children serving as control), all residents of Duayaw Nkwanta, Ghana, were recruited for this case-control study. Venous blood was collected for thick and thin films for malaria microscopy, full blood count by automated haematology analyzer, and antierythropoietin antibody and erythropoietin estimation by sandwich ELISA method.

Results: Out of the 86 participants recruited, only 3 (3.5%) were positive for anti-EPO antibody; 2.3% of the case group; and 1.2% of the control group. There was no association between the cases and the controls in the production of anti-EPO antibodies. Erythropoietin concentration was significantly higher in malaria-related anaemic subjects (p=0.032).

Conclusion: Antierythropoietin antibodies are not associated with malaria infection and malaria-related anaemia in humans. Erythropoietin concentration is associated with malaria-related anaemia.

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