Phosphoinositide 3-kinase and INPP4B in Human Breast Cancer

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2013 Apr 5

PMID 23551093

Citations 21

Authors

Micka C Bertucci

Christina A Mitchell

Affiliations

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Abstract

The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cancer. Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor suppressor in breast cancer. This short review discusses these issues and the possibility that INPP4B is an important regulator in many cancers.

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