Influence of Metabolism on Epigenetics and Disease

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2013 Apr 2

PMID 23540690

Citations 444

Authors

William G Kaelin Jr

Steven L McKnight

Affiliations

Soon will be listed here.

Abstract

Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease. Here, we review literature pertinent to hypothetical connections between metabolic and epigenetic states in eukaryotic cells.

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