Metabolic Cycles As an Underlying Basis of Biological Oscillations

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2006 Jul 11

PMID 16823381

Citations 98

Authors

Benjamin P Tu

Steven L McKnight

Affiliations

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Abstract

The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.

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