Regulation of Monocyte Differentiation by Specific Signaling Modules and Associated Transcription Factor Networks

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2013 Mar 26

PMID 23525665

Citations 26

Authors

Rene Huber

Daniel Pietsch

Johannes Gunther

Bastian Welz

Nico Vogt

Korbinian Brand

Affiliations

Soon will be listed here.

Abstract

Monocyte/macrophages are important players in orchestrating the immune response as well as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are characterized by the interplay between expansion of stem/progenitor cells and progression towards further developed (myelo)monocytic phenotypes. In response to a variety of differentiation-inducing stimuli, various prominent signaling pathways are activated. Subsequently, specific transcription factors are induced, regulating cell proliferation and maturation. This review article focuses on the integration of signaling modules and transcriptional networks involved in the determination of monocytic differentiation.

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