WNT Signaling in Stem Cell Differentiation and Tumor Formation

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2013 Mar 26

PMID 23524963

Citations 5

Authors

Hong Ouyang

Yehong Zhuo

Kang Zhang

Affiliations

Soon will be listed here.

Abstract

Embryonic stem cells (ESCs) hold great therapeutic promise for the regeneration of functional cell types and clinical applications. However, tumorigenic potential of stem cells in a transplanted host remains a major obstacle. In this issue of the JCI, Cui and colleagues identified TCF7-mediated canonical WNT signaling as a critical determinant of both the tumorigenicity and therapeutic function of ESC-derived retinal progenitor cells (ESC-RPCs). Their findings suggested that addressing key extracellular signaling and related intrinsic factors will be essential for the successful use of ESC-derived progenitor transplantation.

Citing Articles

Systematic Analysis of miR-506-3p Target Genes Identified Key Mediators of Its Differentiation-Inducing Function.

Cardus D, Smith M, Vernaza A, Smith J, Del Buono B, Parajuli A Genes (Basel). 2024; 15(10).

PMID: 39457392 PMC: 11507652. DOI: 10.3390/genes15101268.

Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model.

He Y, An J, Yin J, Miao Q, Sui R, Han Q Neurotherapeutics. 2020; 18(1):488-502.

PMID: 33140235 PMC: 8116372. DOI: 10.1007/s13311-020-00947-x.

Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review).

Wang X, Huai G, Wang H, Liu Y, Qi P, Shi W Int J Mol Med. 2017; 41(3):1201-1212.

PMID: 29286147 PMC: 5819904. DOI: 10.3892/ijmm.2017.3352.

Wnt/β-catenin pathway regulates cementogenic differentiation of adipose tissue-deprived stem cells in dental follicle cell-conditioned medium.

Liu N, Gu B, Liu N, Nie X, Zhang B, Zhou X PLoS One. 2014; 9(5):e93364.

PMID: 24806734 PMC: 4012947. DOI: 10.1371/journal.pone.0093364.

Antagonizing Wnt pathway in diabetic retinopathy.

Zhao L, Patel S, Pei J, Zhang K Diabetes. 2013; 62(12):3993-5.

PMID: 24264398 PMC: 3837055. DOI: 10.2337/db13-1309.

References

Zhang K, Ding S . Stem cells and eye development. N Engl J Med. 2011; 365(4):370-2. PMC: 3805038. DOI: 10.1056/NEJMcibr1105280. View

Lamba D, Gust J, Reh T . Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell. 2009; 4(1):73-9. PMC: 2713676. DOI: 10.1016/j.stem.2008.10.015. View

Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T . Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease. Stem Cells. 2012; 30(5):935-45. DOI: 10.1002/stem.1060. View

Przyborski S . Differentiation of human embryonic stem cells after transplantation in immune-deficient mice. Stem Cells. 2005; 23(9):1242-50. DOI: 10.1634/stemcells.2005-0014. View

Kielman M, Rindapaa M, Gaspar C, van Poppel N, Breukel C, van Leeuwen S . Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Nat Genet. 2002; 32(4):594-605. DOI: 10.1038/ng1045. View

Meyer J, Shearer R, Capowski E, Wright L, Wallace K, McMillan E . Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2009; 106(39):16698-703. PMC: 2757802. DOI: 10.1073/pnas.0905245106. View

Osakada F, Ooto S, Akagi T, Mandai M, Akaike A, Takahashi M . Wnt signaling promotes regeneration in the retina of adult mammals. J Neurosci. 2007; 27(15):4210-9. PMC: 6672527. DOI: 10.1523/JNEUROSCI.4193-06.2007. View

West E, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera J, Pearson R . Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells. 2012; 30(7):1424-35. PMC: 3580313. DOI: 10.1002/stem.1123. View

Li W, Sun W, Zhang Y, Wei W, Ambasudhan R, Xia P . Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A. 2011; 108(20):8299-304. PMC: 3100988. DOI: 10.1073/pnas.1014041108. View

10.

Cui L, Guan Y, Qu Z, Zhang J, Liao B, Ma B . WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors. J Clin Invest. 2013; 123(4):1647-61. PMC: 3613909. DOI: 10.1172/JCI65048. View

11.

Schwartz S, Hubschman J, Heilwell G, Franco-Cardenas V, Pan C, Ostrick R . Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet. 2012; 379(9817):713-20. DOI: 10.1016/S0140-6736(12)60028-2. View

12.

Evans M, Kaufman M . Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981; 292(5819):154-6. DOI: 10.1038/292154a0. View

13.

Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S . Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2012; 49(2):359-367. PMC: 3780611. DOI: 10.1016/j.molcel.2012.10.016. View