A Novel Onco-miR-365 Induces Cutaneous Squamous Cell Carcinoma

Overview

Journal Carcinogenesis

Specialty Oncology

Date 2013 Mar 22

PMID 23514750

Citations 41

Authors

Meijuan Zhou

Weilin Liu

Shudong Ma

Hong Cao

XueBiao Peng

Ling Guo

Xinhua Zhou

Li Zheng

Linlang Guo

Miaojian Wan

Weimin Shi

Yingjie He

Chao Lu

Lihong Jiang

Chengshan Ou

Yuanxia Guo

Zhenhua Ding

Affiliations

Soon will be listed here.

Abstract

The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor formation in vivo, along with G1 phase arrest and apoptosis of cancer cells. These findings suggest that miR-365 may act as an onco-miR in cutaneous SCC both in vitro and in vivo. The present study provides valuable insight into the role of miR-365 in cutaneous SCC formation, which can help develop new drug and miR-365 target-based therapies for cutaneous SCC.

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