Non-lactogenic Effects of Growth Hormone on Growth and Insulin-like Growth Factor-I Messenger Ribonucleic Acid of Rat Mammary Gland

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 1990 Jun 1

PMID 2351118

Citations 12

Authors

D L Kleinberg

W Ruan

V Catanese

C B Newman

M Feldman

Affiliations

Soon will be listed here.

Abstract

In contrast to established dogma that PRL is central in mammary development, and GH mimics PRL in affecting growth because of structural similarities, we found that both hGH, which is lactogenic, and rGH, which is non-lactogenic, were significantly more potent than hPRL and rPRL in stimulating mammary growth in rats. Additionally, hGH was more potent than hPRL in increasing mammary IGF-I mRNA content. These data indicate that GH has separate effects on parameters of mammary gland growth, suggesting an independent role for GH in mammary growth.

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