Early Mammary Development: Growth Hormone and IGF-1

Overview

Journal J Mammary Gland Biol Neoplasia

Date 1997 Jan 1

PMID 10887519

Citations 32

Authors

D L Kleinberg

Affiliations

Soon will be listed here.

Abstract

The first step in pubertal mammary development is the appearance of terminal end buds arising from pleuropotent stem cells present in the immature ductal tree of the prepubertal animal. Work from this laboratory indicates that growth hormone is the pituitary hormone responsible for terminal end bud development. Growth hormone likely acts through the production of IGF-1. This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1.

Citing Articles

Metabolomics of Milk Reflects a Negative Energy Balance in Cows.

Xu W, van Knegsel A, Saccenti E, van Hoeij R, Kemp B, Vervoort J J Proteome Res. 2020; 19(8):2942-2949.

PMID: 32633519 PMC: 7426013. DOI: 10.1021/acs.jproteome.9b00706.

Mammary metabolism and colostrogenesis in sows during late gestation and the colostral period.

Feyera T, Zhou P, Nuntapaitoon M, Sorensen K, Krogh U, Bruun T J Anim Sci. 2018; 97(1):231-245.

PMID: 30312406 PMC: 6313141. DOI: 10.1093/jas/sky395.

GLUT1 and lactose synthetase are critical genes for lactose synthesis in lactating sows.

Zhang Y, Zhang S, Guan W, Chen F, Cheng L, Lv Y Nutr Metab (Lond). 2018; 15:40.

PMID: 29946342 PMC: 6001073. DOI: 10.1186/s12986-018-0276-9.

MicroRNA roles in signalling during lactation: an insight from differential expression, time course and pathway analyses of deep sequence data.

Do D, Li R, Dudemaine P, Ibeagha-Awemu E Sci Rep. 2017; 7:44605.

PMID: 28317898 PMC: 5357959. DOI: 10.1038/srep44605.

Effects of the Insulin-like Growth Factor Pathway on the Regulation of Mammary Gland Development.

Ha W, Jeong H, Lee S, Song H Dev Reprod. 2016; 20(3):179-185.

PMID: 27795999 PMC: 5078143. DOI: 10.12717/DR.2016.20.3.179.

References

Kleinberg D, Ruan W, Catanese V, Newman C, Feldman M . Non-lactogenic effects of growth hormone on growth and insulin-like growth factor-I messenger ribonucleic acid of rat mammary gland. Endocrinology. 1990; 126(6):3274-6. DOI: 10.1210/endo-126-6-3274. View

Russo J, Russo I . DNA labeling index and structure of the rat mammary gland as determinants of its susceptibility to carcinogenesis. J Natl Cancer Inst. 1978; 61(6):1451-9. View

Murphy L, Bell G, Friesen H . Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat. Endocrinology. 1987; 120(4):1279-82. DOI: 10.1210/endo-120-4-1279. View

Feldman M, Ruan W, Cunningham B, Wells J, Kleinberg D . Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland. Endocrinology. 1993; 133(4):1602-8. DOI: 10.1210/endo.133.4.8404600. View

Ruan W, Newman C, Kleinberg D . Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development. Proc Natl Acad Sci U S A. 1992; 89(22):10872-6. PMC: 50444. DOI: 10.1073/pnas.89.22.10872. View

Lincoln D, Water M, Breipohl W, Sinowatz F, Lobie P . Growth hormone receptors expression in the proliferating rat mammary gland. Acta Histochem Suppl. 1990; 40:47-9. View

Ruan W, Catanese V, Wieczorek R, Feldman M, Kleinberg D . Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid. Endocrinology. 1995; 136(3):1296-302. DOI: 10.1210/endo.136.3.7867584. View

McGrath M, Collier R, Clemmons D, Busby W, Sweeny C, Krivi G . The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins. Endocrinology. 1991; 129(2):671-8. DOI: 10.1210/endo-129-2-671. View

Nilsson A, Isgaard J, Lindahl A, Dahlstrom A, Skottner A, Isaksson O . Regulation by growth hormone of number of chondrocytes containing IGF-I in rat growth plate. Science. 1986; 233(4763):571-4. DOI: 10.1126/science.3523759. View

10.

Nandi S . Endocrine control of mammarygland development and function in the C3H/ He Crgl mouse. J Natl Cancer Inst. 1958; 21(6):1039-63. View

11.

Glimm D, Baracos V, Kennelly J . Molecular evidence for the presence of growth hormone receptors in the bovine mammary gland. J Endocrinol. 1990; 126(3):R5-8. DOI: 10.1677/joe.0.126r005. View

12.

Leung D, Spencer S, Cachianes G, HAMMONDS R, Collins C, Henzel W . Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature. 1987; 330(6148):537-43. DOI: 10.1038/330537a0. View

13.

Shiu R, Friesen H . Mechanism of action of prolactin in the control of mammary gland function. Annu Rev Physiol. 1980; 42:83-96. DOI: 10.1146/annurev.ph.42.030180.000503. View

14.

LYONS W, Li C, Johnson R . The hormonal control of mammary growth and lactation. Recent Prog Horm Res. 1958; 14:219-48. View

15.

Kleinberg D, Niemann W, Flamm E, Cooper P, Babitsky G, Valensi Q . Primate mammary development. Effects of hypophysectomy, prolactin inhibition, and growth hormone administration. J Clin Invest. 1985; 75(6):1943-50. PMC: 425552. DOI: 10.1172/JCI111910. View

16.

Neuenschwander S, Schwartz A, Wood T, Roberts Jr C, Hennighausen L, LeRoith D . Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. J Clin Invest. 1996; 97(10):2225-32. PMC: 507301. DOI: 10.1172/JCI118663. View

17.

Shiu R, Friesen H . Properties of a prolactin receptor from the rabbit mammary gland. Biochem J. 1974; 140(2):301-11. PMC: 1168001. DOI: 10.1042/bj1400301. View

18.

Jammes H, Gaye P, Belair L, Djiane J . Identification and characterization of growth hormone receptor mRNA in the mammary gland. Mol Cell Endocrinol. 1991; 75(1):27-35. DOI: 10.1016/0303-7207(91)90242-k. View

19.

Schlechter N, Russell S, Spencer E, Nicoll C . Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc Natl Acad Sci U S A. 1986; 83(20):7932-4. PMC: 386837. DOI: 10.1073/pnas.83.20.7932. View

20.

LYONS W . Hormonal synergism in mammary growth. Proc R Soc Lond B Biol Sci. 1958; 149(936):303-25. DOI: 10.1098/rspb.1958.0071. View