Mechanical Overstimulation of Hair Bundles: Suppression and Recovery of Active Motility

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Mar 19

PMID 23505461

Citations 8

Authors

Albert Kao

Sebastiaan W F Meenderink

Dolores Bozovic

Affiliations

Soon will be listed here.

Abstract

We explore the effects of high-amplitude mechanical stimuli on hair bundles of the bullfrog sacculus. Under in vitro conditions, these bundles exhibit spontaneous limit cycle oscillations. Prolonged deflection exerted two effects. First, it induced an offset in the position of the bundle. Recovery to the original position displayed two distinct time scales, suggesting the existence of two adaptive mechanisms. Second, the stimulus suppressed spontaneous oscillations, indicating a change in the hair bundle's dynamic state. After cessation of the stimulus, active bundle motility recovered with time. Both effects were dependent on the duration of the imposed stimulus. External calcium concentration also affected the recovery to the oscillatory state. Our results indicate that both offset in the bundle position and calcium concentration control the dynamic state of the bundle.

Citing Articles

Neural control and innate self-tuning of the hair cell's active process.

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Efferent Activity Controls Hair Cell Response to Mechanical Overstimulation.

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Active Biomechanics of Sensory Hair Bundles.

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Homeostatic enhancement of sensory transduction.

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