Panton-Valentine Leukocidin Staphylococcus Causing Fatal Necrotising Pneumonia in a Young Boy

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2013 Mar 19

PMID 23505079

Citations 10

Authors

Shahzad Haider

David Wright

Affiliations

Soon will be listed here.

Abstract

Panton-Valentine leukocidin (PVL) toxin producing strains of Staphylococcus aureus are known to cause skin and soft tissue infection. They can also cause necrotising pneumonia in otherwise healthy individuals. Here we report a case of severe, necrotising, haemorrhagic pneumonia in a 12-year-old boy who presented with a four-day history of a sore throat and fever. During his admission he deteriorated and needed full ventilatory support but despite all efforts he died. Postmortem examination lung swabs confirmed the presence of PVL-associated S aureus. There is a need to improve awareness of this disease among medical practitioners as early diagnosis and appropriate management can save lives.

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References

Morgan M . Diagnosis and treatment of Panton-Valentine leukocidin (PVL)-associated staphylococcal pneumonia. Int J Antimicrob Agents. 2007; 30(4):289-96. DOI: 10.1016/j.ijantimicag.2007.04.019. View

Lina G, Piemont Y, Bes M, Peter M, Gauduchon V, Vandenesch F . Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999; 29(5):1128-32. DOI: 10.1086/313461. View

Gonzalez B, Hulten K, Dishop M, Lamberth L, Hammerman W, Mason Jr E . Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infection. Clin Infect Dis. 2005; 41(5):583-90. DOI: 10.1086/432475. View

Trieu T, Gaudelus J, Lefevre S, Teychene A, Poilane I, Colignon A . Sudden death caused by Staphylococcus aureus carrying Panton-Valentine leukocidin gene in a young girl. BMJ Case Rep. 2011; 2009. PMC: 3029155. DOI: 10.1136/bcr.02.2009.1542. View

Thomas B, Pugalenthi A, Chilvers M . Pleuropulmonary complications of PVL-positive Staphylococcus aureus infection in children. Acta Paediatr. 2009; 98(8):1372-5. DOI: 10.1111/j.1651-2227.2009.01293.x. View

Mushtaq F, Hildrew S, Okugbeni G, Ellis R, Deshpande S . Necrotizing haemorrhagic pneumonia proves fatal in an immunocompetent child due to Panton-Valentine Leucocidin, toxic shock syndrome toxins 1 and 2 and enterotoxin C-producing Staphylococcus aureus. Acta Paediatr. 2008; 97(7):985-7. DOI: 10.1111/j.1651-2227.2008.00797.x. View

Cunnington A, Brick T, Cooper M, Danin J, Hunt D, Jeanes A . Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK. J Infect. 2009; 59(1):28-36. DOI: 10.1016/j.jinf.2009.05.003. View

Klein J, Petrovic Z, Treacher D, Edgeworth J . Severe community-acquired pneumonia caused by Panton-Valentine leukocidin-positive Staphylococcus aureus: first reported case in the United Kingdom. Intensive Care Med. 2003; 29(8):1399. PMC: 7095159. DOI: 10.1007/s00134-003-1844-6. View

Labandeira-Rey M, Couzon F, Boisset S, Brown E, Bes M, Benito Y . Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science. 2007; 315(5815):1130-3. DOI: 10.1126/science.1137165. View

10.

Holmes A, Ganner M, McGuane S, Pitt T, Cookson B, Kearns A . Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol. 2005; 43(5):2384-90. PMC: 1153723. DOI: 10.1128/JCM.43.5.2384-2390.2005. View

11.

Shallcross L, Williams K, Hopkins S, Aldridge R, Johnson A, Hayward A . Panton-Valentine leukocidin associated staphylococcal disease: a cross-sectional study at a London hospital, England. Clin Microbiol Infect. 2010; 16(11):1644-8. DOI: 10.1111/j.1469-0691.2010.03153.x. View

12.

Freeman H, Hutchings F, Marriage S . Knowledge of Panton-Valentine leukocidin-associated Staphylococcus aureus infections among paediatric registrars in England. Arch Dis Child. 2010; 95(10):855-6. DOI: 10.1136/adc.2010.184655. View

13.

Gillet Y, Vanhems P, Lina G, Bes M, Vandenesch F, Floret D . Factors predicting mortality in necrotizing community-acquired pneumonia caused by Staphylococcus aureus containing Panton-Valentine leukocidin. Clin Infect Dis. 2007; 45(3):315-21. DOI: 10.1086/519263. View

14.

Gillet Y, Issartel B, Vanhems P, Fournet J, Lina G, Bes M . Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet. 2002; 359(9308):753-9. DOI: 10.1016/S0140-6736(02)07877-7. View

15.

Millership S, Cummins A, Irwin D, Kearns A, English P . Follow up of cases of PVL-positive Staphylococcus aureus is not worthwhile. J Infect. 2011; 62(3):234-5. DOI: 10.1016/j.jinf.2011.01.013. View