Quantification of White Matter Injury Following Neonatal Stroke with Serial DTI

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2013 Mar 13

PMID 23478641

Citations 11

Authors

Niek E van der Aa

Frances J Northington

Brian S Stone

Floris Groenendaal

Manon J N L Benders

Giorgio Porro

Shoko Yoshida

Susumu Mori

Linda S de Vries

Jiangyang Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Diffusion tensor imaging (DTI) can be used to predict outcome following perinatal arterial ischemic stroke (PAIS), although little is known about white matter changes over time.

Methods: Infants with PAIS were serially scanned in the neonatal period (n = 15), at 3 mo (n = 16), and at 24 mo (n = 8). Fractional anisotropy (FA) values in five regions of interest (anterior and posterior limb of the internal capsule, corpus callosum, optic radiation, and posterior thalamic radiation) were obtained and compared with FA values of healthy controls and neurodevelopmental outcome.

Results: In the neonatal period, no differences in FA values were found. At 3 mo, the six infants who ultimately developed motor deficits showed lower FA values in all affected regions. Four infants developed a visual field defect and showed lower FA values in the affected optic radiation at 3 mo (0.22 vs. 0.29; P = 0.03). Finally, a correlation between FA values of the corpus callosum at 3 mo and the Griffiths developmental quotients was found (r = 0.66; P = 0.03). At 24 mo, a similar pattern was observed.

Conclusion: Neonatal FA measurements may underestimate the extent of injury following PAIS. FA measurements at 3 mo could be considered a more reliable predictor of neurodevelopmental outcome and correlate with DTI findings at 24 mo.

Citing Articles

Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis.

Baak L, van der Aa N, Verhagen A, Dudink J, Groenendaal F, Nijboer C Pediatr Res. 2022; 94(1):20-33.

PMID: 36575364 DOI: 10.1038/s41390-022-02433-w.

Cerebral ischemia in the developing brain.

Dietz R, Dingman A, Herson P J Cereb Blood Flow Metab. 2022; 42(10):1777-1796.

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Structural brain connectivity in children after neonatal stroke: A whole-brain fixel-based analysis.

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Focal Ischemic Injury to the Early Neonatal Rat Brain Models Cognitive and Motor Deficits with Associated Histopathological Outcomes Relevant to Human Neonatal Brain Injury.

Kagan B, Ermine C, Frausin S, Parish C, Nithianantharajah J, Thompson L Int J Mol Sci. 2021; 22(9).

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In vivo high-resolution diffusion tensor imaging of the developing neonatal rat cortex and its relationship to glial and dendritic maturation.

Breu M, Reisinger D, Tao L, Wu D, Zhang Y, Budde M Brain Struct Funct. 2019; 224(5):1815-1829.

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