Meta-analysis of the Association of the Rs2234693 and Rs9340799 Polymorphisms of Estrogen Receptor Alpha Gene with Coronary Heart Disease Risk in Chinese Han Population

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2013 Mar 9

PMID 23471591

Citations 7

Authors

Chuan-Dong Wei

Hong-Yun Zheng

Wei Wu

Wen Dai

Yong-Qing Tong

Ming Wang

Yan Li

Affiliations

Soon will be listed here.

Abstract

Objective: The association between a common variant of the ESR1 gene rs2234693 and rs9340799 polymorphisms with coronary heart disease (CHD) have been reported, but the available data on this relationship are inconsistent. A meta-analysis was performed to quantitative analysis the association of ESR1 gene polymorphisms and CHD risk using previous case-control studies in Chinese Han population.

Methods: Several electronic databases were searched for relevant articles up to August 2012. After data collection, a meta-analysis was performed to assess heterogeneity, combine results and evaluate variations. Different effect models were used according to the difference in heterogeneity. Sensitivity analysis was assessed by omitting one study at a time. Publication bias was examined using Begg's funnel plot and Egger's linear regression test.

Results: Ten studies covering 3400 subjects on rs2234693 and rs9340799 polymorphisms in the ESR1 gene with CHD risk was included in this meta-analysis. For rs2234693 polymorphism, ten studies were combined to the meta-analysis. A significantly increased CHD risk was found in a dominant model (OR=1.35, 955 CI=1.01-1.81, P=0.05), recessive model (OR=1.40, 95% CI=1.15-1.69, P=0.0007), and additive model (OR=1.67, 95% CI=1.19-2.34, P=0.003). Subgroup for male but not for female showed that the CC genotype could increase the risk of CHD compared with TT and TC genotype in Chinese Han population. Concerning rs9340799 polymorphism, eight studies were combined to the meta-analysis. And no evidence of significant association with CHD risk was found in all genetic models.

Conclusion: Our meta-analysis of 10 studies involving Chinese Han population suggests that the CC genotype of the ESR1 rs2234693 polymorphism is significantly associated with an increased risk of CHD in males only. There was no evidence however, of a significant association between the ESR1 rs9340799 polymorphism and CHD risk.

Citing Articles

Association of the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) Polymorphisms With Risk of Coronary Artery Disease in Iranian Patients.

Miri Karam Z, Yari A, Najmadini A, Khorasani N, Attari R, Jafarinejad-Farsangi S J Clin Lab Anal. 2024; 38(6):e25026.

PMID: 38506378 PMC: 10997818. DOI: 10.1002/jcla.25026.

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD).

Raina J, Sharma M, Panjaliya R, Dogra V, Bakaya A, Kumar P BMC Cardiovasc Disord. 2020; 20(1):340.

PMID: 32682401 PMC: 7368753. DOI: 10.1186/s12872-020-01618-7.

Impact of Genetic Variants in Estrogen Receptor-β Gene in the Etiology of Uterine Leiomyomas.

Bharathi C, Anupama D, Pratibha N, Venkateshwari A J Reprod Infertil. 2019; 20(3):151-160.

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The Association between HMGA1 rs146052672 Variant and Type 2 Diabetes: A Transethnic Meta-Analysis.

Bianco A, Chiefari E, Nobile C, Foti D, Pavia M, Brunetti A PLoS One. 2015; 10(8):e0136077.

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Integration of partial least squares and Monte Carlo gene expression analysis in coronary artery disease.

Zhang H, Li T, Wu G, Ma F Exp Ther Med. 2014; 7(5):1151-1154.

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