Estrogen Receptor α Gene PvuII Polymorphism and Coronary Artery Disease: a Meta-analysis of 21 Studies

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2014 Mar 7

PMID 24599688

Citations 6

Authors

Jie Ding

Hui Xu

Xiang Yin

Fu-Rong Zhang

Xiao-Ping Pan

Yi-An Gu

Jun-Zhu Chen

Xiao-Gang Guo

Affiliations

Soon will be listed here.

Abstract

The association between the estrogen receptor α gene (ESR1) PvuII polymorphism (c.454-397T>C) and coronary artery disease (CAD) is controversial. Thus, we conducted a meta-analysis to evaluate the relationship. Data were collected from 21 studies encompassing 9926 CAD patients and 16710 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the relationship between PvuII polymorphism and CAD. The polymorphism in control populations in all studies followed Hardy-Weinberg equilibrium. We found a significant association between ESR1 PvuII polymorphism and CAD risk in all subjects. When the data were stratified by region, a significant association between ESR1 PvuII polymorphism and CAD risk was observed in Asian populations but not in Western populations. The current study suggests that ESR1 PvuII polymorphism has an important role in CAD susceptibility.

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