Intraoperative Detection of Liver Tumors Aided by a Fluorescence Goggle System and Multimodal Imaging

Overview

Journal Analyst

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2013 Mar 8

PMID 23467534

Citations 9

Authors

Yang Liu

Walter J Akers

Adam Q Bauer

Suman Mondal

Kyle Gullicksrud

Gail P Sudlow

Joseph P Culver

Samuel Achilefu

Affiliations

Soon will be listed here.

Abstract

Real-time image guidance in the operating room is needed to improve instantaneous surgical decisions. Toward this goal, we utilized a new fluorescence goggle system and a near-infrared fluorescent dye approved for human use, indocyanine green, to demonstrate the feasibility of detecting liver tumors intraoperatively. The fluorescence goggle provided successful imaging of multifocal breast cancer metastases in mouse liver. Diffused tumor deposits as small as 0.8 mm in diameter were detected, which were not obvious without the fluorescence goggle. A combination of surface-weighted fluorescence imaging and deep tissue-sensitive ultrasound imaging allowed comprehensive image guidance with the fluorescence goggle system for tumor resection in a rabbit VX2 liver metastasis model. This multimodal detection and guided surgical intervention strategy using ultrasonic imaging and real-time intraoperative fluorescence guidance is a promising and innovative technology platform for improving surgical outcome of human patients with primary or metastatic liver cancer.

Citing Articles

Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery.

Lee S, Quan Y, Kim M, Kwon K, Choi B, Kim H Diagnostics (Basel). 2021; 11(6).

PMID: 34064205 PMC: 8224390. DOI: 10.3390/diagnostics11060927.

An NIR-II/MR dual modal nanoprobe for liver cancer imaging.

Ren Y, He S, Huttad L, Chua M, So S, Guo Q Nanoscale. 2020; 12(21):11510-11517.

PMID: 32428058 PMC: 7959510. DOI: 10.1039/d0nr00075b.

Evaluation of a Tumor-Targeting, Near-Infrared Fluorescent Peptide for Early Detection and Endoscopic Resection of Polyps in a Rat Model of Colorectal Cancer.

Jones J, Busi S, Mitchem J, Amos-Landgraf J, Lewis M Mol Imaging. 2018; 17:1536012118790065.

PMID: 30064304 PMC: 6071153. DOI: 10.1177/1536012118790065.

3D image guidance assisted identification of colorectal cancer liver metastases not seen on intraoperative ultrasound: results from a prospective trial.

Kingham T, Pak L, Simpson A, Leung U, Doussot A, DAngelica M HPB (Oxford). 2017; 20(3):260-267.

PMID: 28935452 PMC: 6717433. DOI: 10.1016/j.hpb.2017.08.035.

Beyond the margins: real-time detection of cancer using targeted fluorophores.

Zhang R, Schroeder A, Grudzinski J, Rosenthal E, Warram J, Pinchuk A Nat Rev Clin Oncol. 2017; 14(6):347-364.

PMID: 28094261 PMC: 5683405. DOI: 10.1038/nrclinonc.2016.212.

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