Binocular Goggle Augmented Imaging and Navigation System Provides Real-time Fluorescence Image Guidance for Tumor Resection and Sentinel Lymph Node Mapping

Overview

Journal Sci Rep

Specialty Science

Date 2015 Jul 17

PMID 26179014

Citations 20

Authors

Suman B Mondal

Shengkui Gao

Nan Zhu

Gail P Sudlow

Kexian Liang

Avik Som

Walter J Akers

Ryan C Fields

Julie Margenthaler

Rongguang Liang

Viktor Gruev

Samuel Achilefu

Affiliations

Soon will be listed here.

Abstract

The inability to identify microscopic tumors and assess surgical margins in real-time during oncologic surgery leads to incomplete tumor removal, increases the chances of tumor recurrence, and necessitates costly repeat surgery. To overcome these challenges, we have developed a wearable goggle augmented imaging and navigation system (GAINS) that can provide accurate intraoperative visualization of tumors and sentinel lymph nodes in real-time without disrupting normal surgical workflow. GAINS projects both near-infrared fluorescence from tumors and the natural color images of tissue onto a head-mounted display without latency. Aided by tumor-targeted contrast agents, the system detected tumors in subcutaneous and metastatic mouse models with high accuracy (sensitivity = 100%, specificity = 98% ± 5% standard deviation). Human pilot studies in breast cancer and melanoma patients using a near-infrared dye show that the GAINS detected sentinel lymph nodes with 100% sensitivity. Clinical use of the GAINS to guide tumor resection and sentinel lymph node mapping promises to improve surgical outcomes, reduce rates of repeat surgery, and improve the accuracy of cancer staging.

Citing Articles

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Fluorescent Probes for Imaging in Humans: Where Are We Now?.

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Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery.

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Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions.

Alfonso-Garcia A, Bec J, Weyers B, Marsden M, Zhou X, Li C J Biophotonics. 2021; 14(6):e202000472.

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Repurposing Molecular Imaging and Sensing for Cancer Image-Guided Surgery.

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