Stability Studies with Amphotericin B and Amphotericin B Methyl Ester

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 1975 Feb 1

PMID 234414

Citations 5

Authors

D P Bonner

W MECHLINSKI

C P SCHAFFNER

Affiliations

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Abstract

In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methy ester salts. However, when pH is adjusted to 6.0 and storage temperature held at 5 degrees C the methyl ester salts reflect the stability exhibited by the parent compound, amphotericin B.

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