The "Observer Effect" in Genome-wide Surveys of Protein-RNA Interactions

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2013 Feb 27

PMID 23438856

Citations 43

Authors

Kasandra J Riley

Joan A Steitz

Affiliations

Soon will be listed here.

Abstract

Recent technological advances have spurred genome-wide studies that afford insights into ribonucleoprotein biology and transcript regulation on an unprecedented scale. Here we review techniques currently used to obtain genome-wide profiles of RNA-protein interactions in living cells. We highlight recent studies of the mRNA-bound proteome and address pitfalls inherent in such investigations.

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