Using the Electroretinogram to Understand How Intraocular Pressure Elevation Affects the Rat Retina

Overview

Journal J Ophthalmol

Publisher Wiley

Specialty Ophthalmology

Date 2013 Feb 23

PMID 23431417

Citations 16

Authors

Bang V Bui

Zheng He

Algis J Vingrys

Christine T O Nguyen

Vickie H Y Wong

Brad Fortune

Affiliations

Soon will be listed here.

Abstract

Intraocular pressure (IOP) elevation is a key risk factor for glaucoma. Our understanding of the effect that IOP elevation has on the eye has been greatly enhanced by the application of the electroretinogram (ERG). In this paper, we describe how the ERG in the rodent eye is affected by changes in IOP magnitude, duration, and number of spikes. We consider how the variables of blood pressure and age can modify the effect of IOP elevation on the ERG. Finally, we contrast the effects that acute and chronic IOP elevation can have on the rodent ERG.

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