MiRNA-181b Suppresses IGF-1R and Functions As a Tumor Suppressor Gene in Gliomas

Overview

Journal RNA

Specialty Molecular Biology

Date 2013 Feb 23

PMID 23431408

Citations 53

Authors

Zhu-Mei Shi

Xie-Feng Wang

Xu Qian

Tao Tao

Lin Wang

Qiu-Dan Chen

Xi-Rui Wang

Lei Cao

Ying-Yi Wang

Jun-xia Zhang

Tao Jiang

Chun-Sheng Kang

Bing-Hua Jiang

Ning Liu

Yong-ping You

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are single-stranded, 18- to 23-nt RNA molecules that function as regulators of gene expression. Previous studies have shown that microRNAs play important roles in human cancers, including gliomas. Here, we found that expression levels of miR-181b were decreased in gliomas, and we identified IGF-1R as a novel direct target of miR-181b. MiR-181b overexpression inhibited cell proliferation, migration, invasion, and tumorigenesis by targeting IGF-1R and its downstream signaling pathways, PI3K/AKT and MAPK/ERK1/2. Overexpression of IGF-1R rescued the inhibitory effects of miR-181b. In clinical specimens, IGF-1R was overexpressed, and its protein levels were inversely correlated with miR-181b expression. Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas.

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