Related F-box Proteins Control Cell Death in Caenorhabditis Elegans and Human Lymphoma

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2013 Feb 23

PMID 23431138

Citations 40

Authors

Michael Chiorazzi

Lixin Rui

Yandan Yang

Michele Ceribelli

Nima Tishbi

Carine W Maurer

Stella M Ranuncolo

Hong Zhao

Weihong Xu

Wing-Chung C Chan

Elaine S Jaffe

Randy D Gascoyne

Elias Campo

Andreas Rosenwald

German Ott

Jan Delabie

Lisa M Rimsza

Shai Shaham

Louis M Staudt

Affiliations

Soon will be listed here.

Abstract

Cell death is a common metazoan cell fate, and its inactivation is central to human malignancy. In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the caspase CED-3 following binding of the EGL-1/BH3-only protein to the antiapoptotic CED-9/BCL2 protein. Here we report a major alternative mechanism for caspase activation in vivo involving the F-box protein DRE-1. DRE-1 functions in parallel to EGL-1, requires CED-9 for activity, and binds to CED-9, suggesting that DRE-1 promotes apoptosis by inactivating CED-9. FBXO10, a human protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some human diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels. Our results suggest that DRE-1/FBXO10 is a conserved regulator of apoptosis.

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