External Cavity Laser Biosensor

Overview

Journal Lab Chip

Publisher Royal Society of Chemistry

Specialties Biotechnology
Chemistry

Date 2013 Feb 23

PMID 23429747

Citations 11

Authors

Chun Ge

Meng Lu

Sherine George

Timothy A Flood Jr

Clark Wagner

Jie Zheng

Anusha Pokhriyal

J Gary Eden

Paul J Hergenrother

Brian T Cunningham

Affiliations

Soon will be listed here.

Abstract

Utilizing a tunable photonic crystal resonant reflector as a mirror of an external cavity laser cavity, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity and large dynamic range. The photonic crystal is fabricated inexpensively from plastic materials, and its resonant wavelength is tuned by adsorption of biomolecules on its surface. Gain for the lasing process is provided by a semiconductor optical amplifier, resulting in a simple detection instrument that operates by normally incident noncontact illumination of the photonic crystal and direct back-reflection into the amplifier. We demonstrate single-mode, biomolecule-induced tuning of the continuous-wave laser wavelength. Because the approach incorporates external optical gain that is separate from the transducer, the device represents a significant advance over previous passive optical resonator biosensors and laser-based biosensors.

Citing Articles

Asymmetric tetramer metasurface sensor governed by quasi-bound states in the continuum.

Zhou Y, Luo M, Zhao X, Li Y, Wang Q, Liu Z Nanophotonics. 2024; 12(7):1295-1307.

PMID: 39677591 PMC: 11636488. DOI: 10.1515/nanoph-2023-0003.

Exploiting Thin-Film Properties and Guided-Mode Resonance for Designing Ultrahigh-Figure-of-Merit Refractive Index Sensors.

Cu D, Wu H, Chen H, Su L, Kuo C Sensors (Basel). 2024; 24(3).

PMID: 38339677 PMC: 10856855. DOI: 10.3390/s24030960.

Label-Free Bound-States-in-the-Continuum Biosensors.

Luo M, Zhou Y, Zhao X, Li Y, Guo Z, Yang X Biosensors (Basel). 2022; 12(12).

PMID: 36551087 PMC: 9775062. DOI: 10.3390/bios12121120.

Guided Mode Resonance Sensors with Optimized Figure of Merit.

Zhou Y, Wang B, Guo Z, Wu X Nanomaterials (Basel). 2019; 9(6).

PMID: 31159384 PMC: 6631114. DOI: 10.3390/nano9060837.

Porous photonic crystal external cavity laser biosensor.

Huang Q, Peh J, Hergenrother P, Cunningham B Appl Phys Lett. 2016; 109(7):071103.

PMID: 27647941 PMC: 4991988. DOI: 10.1063/1.4961107.

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