Distribution of Non-telomeric Sites of the (TTAGGG)n Telomeric Sequence in Vertebrate Chromosomes

Overview

Journal Chromosoma

Specialty Molecular Biology

Date 1990 Apr 1

PMID 2340757

Citations 209

Authors

J Meyne

R J Baker

H H Hobart

T C Hsu

O A Ryder

O G Ward

J E Wiley

T L Yates

R K Moyzis

Affiliations

Soon will be listed here.

Abstract

The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.

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