Elevated Levels of High-mobility Group Box-1 (HMGB1) in Patients with Severe or Uncomplicated Plasmodium Falciparum Malaria

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2013 Feb 13

PMID 23400574

Citations 6

Authors

Davide Angeletti

Mpungu Steven Kiwuwa

Justus Byarugaba

Fred Kironde

Mats Wahlgren

Affiliations

Soon will be listed here.

Abstract

Severe malaria is characterized by a massive release of proinflammatory cytokines in the context of sequestration of parasitized and normal red cells (RBCs). High-mobility group box 1 (HMGB1) is a DNA- and heparin-binding protein that also acts as a cytokine when released from cells in the extracellular milieu after a proinflammatory stimulus. In this study, we have measured the circulating levels of HMGB1 in 76 children with severe or uncomplicated malaria. Sera from both severe (P = 0.0022) and uncomplicated (P = 0.0049) patients had significantly higher circulating HMGB1 levels compared with healthy controls. Elevated HMGB1 in patients with ongoing Plasmodium falciparum infections might prolong inflammation and the febrile state of malaria and could offer a potential target for therapeutic intervention.

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