The Transcription Factor Early B-cell Factor 1 Regulates Bone Formation in an Osteoblast-nonautonomous Manner

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2013 Feb 12

PMID 23395800

Citations 5

Authors

Tiffany Zee

Soren Boller

Ildiko Gyory

Munevver P Makinistoglu

Jan P Tuckermann

Rudolf Grosschedl

Gerard Karsenty

Affiliations

Soon will be listed here.

Abstract

Early B-cell factor 1 (Ebf1) is a transcription factor whose inactivation in all cells results in high bone mass because of an increase in bone formation. This observation suggests Ebf1 may be an inhibitor of osteoblast differentiation. To test this contention, we analyzed Ebf1 pattern of expression and function in osteoblasts ex vivo and in vivo through osteoblast-specific inactivation in the mouse. We show here that in vivo deletion of Ebf1 in osteoblast progenitors does not affect osteoblast differentiation or bone formation accrual post-natally. These observations indicate that the phenotype described in Ebf1(-/)(-) mice is not osteoblast-autonomous.

Citing Articles

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