Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnosis and Management

Overview

Journal Br J Haematol

Specialty Hematology

Date 2013 Feb 7

PMID 23384054

Citations 47

Authors

Julie A Peterson

Janice G McFarland

Brian R Curtis

Richard H Aster

Affiliations

Soon will be listed here.

Abstract

Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.

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