The Development of Severe Neonatal Alloimmune Thrombocytopenia Due to Anti-HPA-1a Antibodies is Correlated to Maternal ABO Genotypes

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2011 Nov 24

PMID 22110529

Citations 5

Authors

Maria Therese Ahlen

Anne Husebekk

Mette Kjaer Killie

Jens Kjeldsen-Kragh

Martin L Olsson

Bjorn Skogen

Affiliations

Soon will be listed here.

Abstract

Background: Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies.

Design And Methods: A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated.

Results: We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25-0.75).

Conclusion: The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side.

Citing Articles

ABO Incompatibility between the Mother and Fetus Does Not Protect against Anti-Human Platelet Antigen-1a Immunization by Pregnancy.

Miserre L, Wienzek-Lischka S, Mann A, Cooper N, Santoso S, Ehrhardt H J Clin Med. 2022; 11(22).

PMID: 36431288 PMC: 9694632. DOI: 10.3390/jcm11226811.

Neonatal Immune Incompatibilities between Newborn and Mother.

Arneth B J Clin Med. 2020; 9(5).

PMID: 32422924 PMC: 7291300. DOI: 10.3390/jcm9051470.

Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention.

Brojer E, Husebekk A, Debska M, Uhrynowska M, Guz K, Orzinska A Arch Immunol Ther Exp (Warsz). 2015; 64(4):279-90.

PMID: 26564154 PMC: 4939163. DOI: 10.1007/s00005-015-0371-9.

Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management.

Peterson J, McFarland J, Curtis B, Aster R Br J Haematol. 2013; 161(1):3-14.

PMID: 23384054 PMC: 3895911. DOI: 10.1111/bjh.12235.

Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.

Desch K, Ozel A, Siemieniak D, Kalish Y, Shavit J, Thornburg C Proc Natl Acad Sci U S A. 2012; 110(2):588-93.

PMID: 23267103 PMC: 3545809. DOI: 10.1073/pnas.1219885110.

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