Correlation Between Vertical Transmission of Hepatitis B Virus and the Expression of HBsAg in Ovarian Follicles and Placenta

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Feb 6

PMID 23382883

Citations 10

Authors

Minmin Yu

Qian Jiang

Xiaojun Gu

Lili Ju

Ying Ji

Kaihua Wu

Hongxiu Jiang

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this study was to investigate the correlation between the expression of hepatitis B surface antigen (HBsAg) in human ovary and placenta and the vertical transmission of hepatitis B virus (HBV).

Methodology/principal Fidnings: Ovarian and placental tissue specimens of pregnant women infected with HBV were collected during cesarean section and immunostained for HBsAg. The sera of the corresponding newborns were tested for HBV markers and HBV DNA. HBsAg was detected in 15 out of 33 (45%) placental tissues and was further detected in capillary endothelial cells in 4 specimens (26%), of which 3 (75%) corresponding infants were infected with HBV in utero. Out of the 33 ovarian tissues, 7 (21%) were positive for HBsAg, of which 2 (28%) showed HBsAg in ovarian follicles and the 2 corresponding infants (100%) had intrauterine HBV infection.

Conclusions/significance: HBsAg expression in cells of the ovarian follicle or placental capillary endothelium signal a higher risk for intrauterine HBV infection.

Citing Articles

Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment.

Li Y, Wang X, Jiang Y, Lv Q, Zhang Y, Wang Y BMC Med. 2025; 23(1):58.

PMID: 39901129 PMC: 11792308. DOI: 10.1186/s12916-025-03905-6.

Strategies to Prevent Mother-to-child Transmission of Hepatitis B Virus.

Sintusek P, Wanlapakorn N, Poovorawan Y J Clin Transl Hepatol. 2023; 11(4):967-974.

PMID: 37408824 PMC: 10318275. DOI: 10.14218/JCTH.2022.00332.

Vertical Transmission of Hepatitis B Virus-An Update.

di Filippo Villa D, Navas M Microorganisms. 2023; 11(5).

PMID: 37317114 PMC: 10221798. DOI: 10.3390/microorganisms11051140.

Prevalence of hepatitis B and C virus infections in Lao People's Democratic Republic: The first national population-based cross-sectional survey.

Miyano S, Pathammavong C, Ichimura Y, Sugiyama M, Phounphenghack K, Tengbriacheu C PLoS One. 2022; 17(12):e0278933.

PMID: 36584043 PMC: 9803141. DOI: 10.1371/journal.pone.0278933.

Benefits and Risks of Antiviral Treatment during Pregnancy in Patients with Chronic Hepatitis B.

Lee Y, Bang S, Lee Y J Clin Med. 2021; 10(11).

PMID: 34073357 PMC: 8198811. DOI: 10.3390/jcm10112320.

References

Ye F, Yue Y, Li S, Chen T, Zhang S, Bai G . Expression of HBsAg and HBcAg in the ovaries and ova of patients with chronic hepatitis B. World J Gastroenterol. 2005; 11(36):5718-20. PMC: 4481496. DOI: 10.3748/wjg.v11.i36.5718. View

Chen L, Fan X, Gao J . Detection of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection. World J Gastroenterol. 2005; 11(35):5565-7. PMC: 4320374. DOI: 10.3748/wjg.v11.i35.5565. View

Bhat P, Anderson D . Hepatitis B virus translocates across a trophoblastic barrier. J Virol. 2007; 81(13):7200-7. PMC: 1933314. DOI: 10.1128/JVI.02371-06. View

Hadchouel M, Scotto J, Huret J, MOLINIE C, Villa E, Degos F . Presence of HBV DNA in spermatozoa: a possible vertical transmission of HBV via the germ line. J Med Virol. 1985; 16(1):61-6. DOI: 10.1002/jmv.1890160109. View

Davison F, Alexander G, Trowbridge R, Fagan E, Williams R . Detection of hepatitis B virus DNA in spermatozoa, urine, saliva and leucocytes, of chronic HBsAg carriers. A lack of relationship with serum markers of replication. J Hepatol. 1987; 4(1):37-44. DOI: 10.1016/s0168-8278(87)80007-7. View

Ma J, Bai G, Feng L . [Study on hepatitis B virus infection status in placentas of hepatitis B surface antigen positive pregnant women during middle and late period of pregnancy]. Zhonghua Fu Chan Ke Za Zhi. 2001; 35(11):654-6. View

Zhang S, Yue Y, Bai G, Shi L, Jiang H . Mechanism of intrauterine infection of hepatitis B virus. World J Gastroenterol. 2004; 10(3):437-8. PMC: 4724928. DOI: 10.3748/wjg.v10.i3.437. View

Ursell P, Habib A, Sharma P, Lefkowitch J, Fenoglio Jr J . Hepatitis B virus and myocarditis. Hum Pathol. 1984; 15(5):481-4. DOI: 10.1016/s0046-8177(84)80085-4. View

Huang J, Deng Q, Wang Q, Li K, Dai J, Li N . Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat Genet. 2012; 44(10):1117-21. DOI: 10.1038/ng.2391. View

10.

Ali B, Huang T, Xie Q . Detection and expression of hepatitis B virus X gene in one and two-cell embryos from golden hamster oocytes in vitro fertilized with human spermatozoa carrying HBV DNA. Mol Reprod Dev. 2004; 70(1):30-6. DOI: 10.1002/mrd.20185. View

11.

Bai G, Li S, Yue Y, Shi L . The study on role of peripheral blood mononuclear cell in HBV intrauterine infection. Arch Gynecol Obstet. 2010; 283(2):317-21. DOI: 10.1007/s00404-010-1366-8. View

12.

Lou H, Ding W, Dong M, Zhu Y, Zhou C, Wang Z . The presence of hepatitis B surface antigen in the ova of pregnant women and its relationship with intra-uterine infection by hepatitis B virus. J Int Med Res. 2010; 38(1):214-9. DOI: 10.1177/147323001003800125. View

13.

Amarapurkar D, Amarapurkar A . Extrahepatic manifestations of viral hepatitis. Ann Hepatol. 2004; 1(4):192-5. View

14.

Han S . Extrahepatic manifestations of chronic hepatitis B. Clin Liver Dis. 2004; 8(2):403-18. DOI: 10.1016/j.cld.2004.02.003. View

15.

Wang A, Wang A, Xu D, Men K, Yan Y, Zhang J . [The mechanism of HBV infection of human trophoblast cell]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008; 22(1):51-3. View

16.

Gatta A, Giannini C, Lampertico P, Pontisso P, Quarta S, Zignego A . Hepatotropic viruses: new insights in pathogenesis and treatment. Clin Exp Rheumatol. 2008; 26(1 Suppl 48):S33-8. View

17.

Bai H, Zhang L, Ma L, Dou X, Feng G, Zhao G . Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism. World J Gastroenterol. 2007; 13(26):3625-30. PMC: 4146804. DOI: 10.3748/wjg.v13.i26.3625. View

18.

Lin C . Hepatitis B virus deoxyribonucleic acid in kidney cells probably leading to viral pathogenesis among hepatitis B virus associated membranous nephropathy patients. Nephron. 1993; 63(1):58-64. DOI: 10.1159/000187144. View

19.

Ranger-Rogez S, Alain S, Denis F . [Hepatitis viruses: mother to child transmission]. Pathol Biol (Paris). 2002; 50(9):568-75. DOI: 10.1016/s0369-8114(02)00351-6. View

20.

Ye F, Yue Y, Li S, Chen T, Bai G, Liu M . Presence of HBsAg, HBcAg, and HBVDNA in ovary and ovum of the patients with chronic hepatitis B virus infection. Am J Obstet Gynecol. 2006; 194(2):387-92. DOI: 10.1016/j.ajog.2005.07.011. View