EEG Correlates of Time-varying BOLD Functional Connectivity

Overview

Journal Neuroimage

Specialty Radiology

Date 2013 Feb 5

PMID 23376790

Citations 180

Authors

Catie Chang

Zhongming Liu

Michael C Chen

Xiao Liu

Jeff H Duyn

Affiliations

Soon will be listed here.

Abstract

Recent resting-state fMRI studies have shown that the apparent functional connectivity (FC) between brain regions may undergo changes on time-scales of seconds to minutes, the basis and importance of which are largely unknown. Here, we examine the electrophysiological correlates of within-scan FC variations during a condition of eyes-closed rest. A sliding window analysis of simultaneous EEG-fMRI data was performed to examine whether temporal variations in coupling between three major networks (default mode; DMN, dorsal attention; DAN, and salience network; SN) are associated with temporal variations in mental state, as assessed from the amplitude of alpha and theta oscillations in the EEG. In our dataset, alpha power showed a significant inverse relationship with the strength of connectivity between DMN and DAN. In addition, alpha power covaried with the spatial extent of anticorrelation between DMN and DAN, with higher alpha power associated with larger anticorrelation extent. Results suggest an electrical signature of the time-varying FC between the DAN and DMN, potentially reflecting neural and state-dependent variations.

Citing Articles

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References

Klimesch W . EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res Brain Res Rev. 1999; 29(2-3):169-95. DOI: 10.1016/s0165-0173(98)00056-3. View

Scheeringa R, Petersson K, Kleinschmidt A, Jensen O, Bastiaansen M . EEG α power modulation of fMRI resting-state connectivity. Brain Connect. 2012; 2(5):254-64. PMC: 3621304. DOI: 10.1089/brain.2012.0088. View

Sporns O . The non-random brain: efficiency, economy, and complex dynamics. Front Comput Neurosci. 2011; 5:5. PMC: 3037776. DOI: 10.3389/fncom.2011.00005. View

Horovitz S, Fukunaga M, de Zwart J, van Gelderen P, Fulton S, Balkin T . Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study. Hum Brain Mapp. 2007; 29(6):671-82. PMC: 6871022. DOI: 10.1002/hbm.20428. View

Smallwood J, Davies J, Heim D, Finnigan F, Sudberry M, OConnor R . Subjective experience and the attentional lapse: task engagement and disengagement during sustained attention. Conscious Cogn. 2004; 13(4):657-90. DOI: 10.1016/j.concog.2004.06.003. View

Kiviniemi V, Vire T, Remes J, Abou Elseoud A, Starck T, Tervonen O . A sliding time-window ICA reveals spatial variability of the default mode network in time. Brain Connect. 2012; 1(4):339-47. DOI: 10.1089/brain.2011.0036. View

Jenkinson M, Bannister P, Brady M, Smith S . Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002; 17(2):825-41. DOI: 10.1016/s1053-8119(02)91132-8. View

Shmuel A, Leopold D . Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest. Hum Brain Mapp. 2008; 29(7):751-61. PMC: 6870786. DOI: 10.1002/hbm.20580. View

Vanhaudenhuyse A, Noirhomme Q, Tshibanda L, Bruno M, Boveroux P, Schnakers C . Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain. 2009; 133(Pt 1):161-71. PMC: 2801329. DOI: 10.1093/brain/awp313. View

10.

Greicius M, Krasnow B, Reiss A, Menon V . Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A. 2002; 100(1):253-8. PMC: 140943. DOI: 10.1073/pnas.0135058100. View

11.

Magri C, Schridde U, Murayama Y, Panzeri S, Logothetis N . The amplitude and timing of the BOLD signal reflects the relationship between local field potential power at different frequencies. J Neurosci. 2012; 32(4):1395-407. PMC: 6796252. DOI: 10.1523/JNEUROSCI.3985-11.2012. View

12.

Chang C, Glover G . Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. Neuroimage. 2009; 47(4):1448-59. PMC: 2995588. DOI: 10.1016/j.neuroimage.2009.05.012. View

13.

Larson-Prior L, Power J, Vincent J, Nolan T, Coalson R, Zempel J . Modulation of the brain's functional network architecture in the transition from wake to sleep. Prog Brain Res. 2011; 193:277-94. PMC: 3811144. DOI: 10.1016/B978-0-444-53839-0.00018-1. View

14.

de Munck J, Goncalves S, Faes T, Kuijer J, Pouwels P, Heethaar R . A study of the brain's resting state based on alpha band power, heart rate and fMRI. Neuroimage. 2008; 42(1):112-21. DOI: 10.1016/j.neuroimage.2008.04.244. View

15.

Hamilton J, Furman D, Chang C, Thomason M, Dennis E, Gotlib I . Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination. Biol Psychiatry. 2011; 70(4):327-33. PMC: 3144981. DOI: 10.1016/j.biopsych.2011.02.003. View

16.

Lu H, Zuo Y, Gu H, Waltz J, Zhan W, Scholl C . Synchronized delta oscillations correlate with the resting-state functional MRI signal. Proc Natl Acad Sci U S A. 2007; 104(46):18265-9. PMC: 2084331. DOI: 10.1073/pnas.0705791104. View

17.

Glover G, Law C . Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts. Magn Reson Med. 2001; 46(3):515-22. DOI: 10.1002/mrm.1222. View

18.

Samann P, Wehrle R, Hoehn D, Spoormaker V, Peters H, Tully C . Development of the brain's default mode network from wakefulness to slow wave sleep. Cereb Cortex. 2011; 21(9):2082-93. DOI: 10.1093/cercor/bhq295. View

19.

Fransson P . Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Hum Brain Mapp. 2005; 26(1):15-29. PMC: 6871700. DOI: 10.1002/hbm.20113. View

20.

Hlinka J, Alexakis C, Diukova A, Liddle P, Auer D . Slow EEG pattern predicts reduced intrinsic functional connectivity in the default mode network: an inter-subject analysis. Neuroimage. 2010; 53(1):239-46. DOI: 10.1016/j.neuroimage.2010.06.002. View