Human Systems Immunology: Hypothesis-based Modeling and Unbiased Data-driven Approaches

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2013 Feb 5

PMID 23375135

Citations 17

Authors

Arnon Arazi

William F Pendergraft 3rd

Ruy M Ribeiro

Alan S Perelson

Nir Hacohen

Affiliations

Soon will be listed here.

Abstract

Systems immunology is an emerging paradigm that aims at a more systematic and quantitative understanding of the immune system. Two major approaches have been utilized to date in this field: unbiased data-driven modeling to comprehensively identify molecular and cellular components of a system and their interactions; and hypothesis-based quantitative modeling to understand the operating principles of a system by extracting a minimal set of variables and rules underlying them. In this review, we describe applications of the two approaches to the study of viral infections and autoimmune diseases in humans, and discuss possible ways by which these two approaches can synergize when applied to human immunology.

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