Making the Clock Tick: Right Time, Right Pace
Overview
Reproductive Medicine
Authors
Affiliations
Two studies from Delaune et al. (2012) and Harima et al. (2012), published in Developmental Cell and Cell Reports, respectively, used elegant genetic and imaging techniques to shed new light on the role of the Notch pathway in regulating the pace and synchronization of the segmentation clock.
Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion.
Ubezio B, Blanco R, Geudens I, Stanchi F, Mathivet T, Jones M Elife. 2016; 5.
PMID: 27074663 PMC: 4894757. DOI: 10.7554/eLife.12167.
Regulation of transcriptional bursting by a naturally oscillating signal.
Corrigan A, Chubb J Curr Biol. 2014; 24(2):205-211.
PMID: 24388853 PMC: 3928820. DOI: 10.1016/j.cub.2013.12.011.