Dry Eye As a Mucosal Autoimmune Disease

Overview

Journal Int Rev Immunol

Publisher Informa Healthcare

Specialty Allergy & Immunology

Date 2013 Jan 31

PMID 23360156

Citations 146

Authors

Michael E Stern

Chris S Schaumburg

Stephen C Pflugfelder

Affiliations

Soon will be listed here.

Abstract

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular surface homeostasis, facilitating chronic inflammation and tissue damage. Accordingly, the most effective treatments to date are geared towards reducing inflammation and restoring normal tear film. The pathogenic role of CD4+ T cells is well known, and the field is rapidly realizing the complexity of other innate and adaptive immune factors involved in the development and progression of disease. The data support the hypothesis that dry eye is a localized autoimmune disease originating from an imbalance in the protective immunoregulatory and proinflammatory pathways of the ocular surface.

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