The C-jun Kinase/stress-activated Pathway: Regulation, Function and Role in Human Disease

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2007 Feb 20

PMID 17306896

Citations 223

Authors

Gary L Johnson

Kazuhiro Nakamura

Affiliations

Soon will be listed here.

Abstract

c-Jun N-terminal kinases (JNKs), also referred to as stress-activated kinases (SAPKs), were initially characterized by their activation in response to cell stress such as UV irradiation. JNK/SAPKs have since been characterized to be involved in proliferation, apoptosis, motility, metabolism and DNA repair. Dysregulated JNK signaling is now believed to contribute to many diseases involving neurodegeneration, chronic inflammation, birth defects, cancer and ischemia/reperfusion injury. In this review, we present our current understanding of JNK regulation and their involvement in homeostasis and dysregulation in human disease.

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